Leishmanicidal Active Withanolides from a Pakistani Medicinal Plant, Withania coagulans
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概要
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In the course of screening for leishmanicidal constituents from Asian and South American medicinal plants, a Pakistani medicinal plant, Withania coagulans, showed activity. We therefore studied the active components of the methanol extract of aerial parts of W. coagulans. From the ethyl acetate soluble fraction of the extract, four new withanolides (1–4) were isolated along with seven known withanolides (5–11). The new compounds were elucidated to be (14R,15R,17S,20S,22R)-14,15,17,20-tetrahydroxy-1-oxowitha-2,5,24-trienolide (1), (14R,15R,17S,20S,22R)-14,15,17,20-tetrahydroxy-1-oxowitha-3,5,24-trienolide (2), (14S,17R,20S,22R)-14,17,20-trihydroxy-1-oxowitha-2,5,24-trienolide (3), and (14S,17R,20S,22R)-14,17,20-trihydroxy-1-oxowitha-3,5,24-trienolide (4), from 1H-NMR, 13C-NMR, 2D-NMR and high resolution (HR)-MS data. Some of these compounds having the partial structure 1-oxo-2,5-diene showed strong leishmanicidal activity against Leishmania major.
著者
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NAKANE Takahisa
Showa Pharmaceutical University
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Shirota Osamu
Faculty Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri University
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Sekita Setsuko
Faculty Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri University
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Fuchino Hiroyuki
Research Center For Medicinal Plant Resources National Institute Of Biomedical Innovation
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Nakane Takahisa
Biological Sci. Res. Lab. Lion Corp.
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Nakane Takahisa
Showa Pharmaceutical Univ.
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Shinwari Zabta
Department Of Botany Faculty Of Science Kyoto University:(present Address)pakistan Museum Of Natural
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Kuroyanagi Masanori
Faculty Of Food Culture Department Of Nutrition Kurashiki Sakuyo University
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Murata Miki
Faculty of Life and Enviromental Sciences, Prefectural University of Hiroshima
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Sekita Setsuko
Faculty of Pharmaceutical Sciemces at Kagawa Campus, Tokushima Bunri Universiyty
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Shirota Osamu
Faculty of Pharmaceutical Sciemces at Kagawa Campus, Tokushima Bunri Universiyty
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Shinwari Zabta
Department of Biotechnology, Quaid-i-Azam University
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Kuroyanagi Masanori
Faculty of Pharmaceutical Sciemces at Kagawa Campus, Tokushima Bunri Universiyty
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Nakane Takahisa
Showa Parmaceutical University
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