Novel Lanostane and Rearranged Lanostane-Type Triterpenoids from Abies sachalinensis-II-
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概要
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In the previous work we reported five A-seco-rearranged lanostane triterpenoids as antibacterial constituents from the ethyl acetate soluble fraction of Abies sachalinensei leaves. In further study on the isolation of constituents from the ethyl acetate soluble fraction, two new rearranged lanostane and lanostane-type triterpenoids (3,4) and three reported compound (1, 2, 5) were isolated. The structures of new compound 3 and 4 were determined to be 3,4-seco-4(28),6,8(14),24-mariesatetraen-26,23-olide-23-hydroxy-3-oic acid and 3,4-seco-4(28),7,24-lanostatrien-26,23-olide-23-hydroxy-3-oic acid, respectively, by spectral studies on HR-MS, ^1H-NMR, ^<13>C-NMR, and 2D-NMR spectra. Compound 1 was identified with pindrolactone and its structure was revised as 7,14,22Z,24-mariesatetraen-26,23-olide-3α-ol. Structures of 2 and 5 were determined as 7,14,24-mariesatrien-26,23-olide-3α,23-diol and 3α-hydroxy-7,14,24E-mariesatrien-23-oxo-26-oic acid. Of these compounds, 2, 3 and 4 were obtained as lactol tautomer mixtures at γ-lactone structures of side chains.
- 社団法人日本薬学会の論文
- 2008-04-01
著者
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Wu Lijun
中華人民共和国
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Wu Li
School Of Traditional Chinese Materia Medica Shenyang Pharmaceutical University
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SHIROTA Osamu
Faculty of Pharmaceutical Sciences, Kagawa Campus, Tokushima Bunri University
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Gao H
School Of Traditional Chinese Medicines Shenyang Pharaceutical University
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Gao Hui
School Of Traditional Chinese Medicines Shenyang Pharmaceutical University
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Kuroyanagi M
Fac. Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri Univ.
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Shirota Osamu
Faculty Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri University
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Shirota Osamu
Shiseido Research Center
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Wu Li
School Of Traditional Chinese Medicines Shenyang Pharmaceutical University
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NAKANE Takahisa
Shouwa Pharmaceutical University
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KUROYANAGI Masonori
Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima
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Wang Li-bo
Kyoto Pharmaceutical University:faculty Of Natural Medicines Shenyang Pharmaceutical University
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Nakane Takahisa
Biological Sci. Res. Lab. Lion Corp.
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Nakane Takahisa
Showa Pharmaceutical Univ.
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Kuroyanagi Masanori
Fac. Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri Univ.
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Kimura Mariko
Fac. Of Food Culture Dep. Of Nutrition Kurashiki Sakuyo Univ.
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Ohta Sanae
Laboratory Of Pharmacognosy And Natural Product Chemistry Faculty Of Pharmaceutical Sciences At Kaga
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Shirota Osamu
Faculty of Pharmaceutical Sciemces at Kagawa Campus, Tokushima Bunri Universiyty
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GAO Hui
School of Information and Communication Engineering, Beijing University of Posts and Telecommunications
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