Anti-androgenic Triterpenoids from the Brazilian Medicinal Plant, Cordia multispicata
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概要
- 論文の詳細を見る
Compounds 1-6 were isolated from the AcOEt soluble fraction of leaves of the Brazilian medicinal plant, Cardia multispicata, and their structures were elucidated to be 3β, 25-epoxy-21β-acetoxy-3α, 22β-dihydroxyurs-12-en-28-al(1), 3β, 25-epoxy-28-acetoxy-3α, 21β, 22β-trihydroxyurs-12-ene(2), 21β-acetoxy-22β-hydroxy-3-ox-ours-12-en-28-al(3), 28-acetoxy-6β, 21β, 21β-trihydroxy-3-oxours-12-ene(4), 21β, 22β-dihydroxy-3-oxours-12-en-28-al(5) and 3β, 21β, 22β-trihydroxyurs-12-en-28-al(6), respectively, by means of spectral data, especially two dimensional NMR techiques. Triterpenes having the hemiketal structure at the A-ring, an acyloxy group at C-22 and/or ketone at C-3 showed potent anti-androgenic activity.
- 公益社団法人日本薬学会の論文
- 2001-08-01
著者
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KAWAHARA Nobuo
Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences
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KUROYANAGI Masanori
School of Bioresources, Hiroshioma Prefectural University
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SATAKE Motoyoshi
Division of Pharmacognosy and Phytochemistry, National Institute of Health Sciences
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Satake M
Institute Of Environmental Science For Human Life Ochanomizu University
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Kuroyanagi M
Fac. Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri Univ.
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Sekita Setsuko
大阪府立公衆衛生研究所
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Sekita Setsuko
Division Of Pharmacognosy And Phytochemistry National Institute Of Health Sciences
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Sekita Setsuko
National Institute Of Health Sciences
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Satake Motoyoshi
Division Of Pharmacognosy Phytochemistry And Narcotics National Institute Of Health Sciences
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Satake M
National Inst. Health Sci. Tokyo Jpn
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Satake Motoyoshi
Division Of Pharmacognosy And Phytochemistry National Institute Of Health Sciences
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Sekita Setsuko
湧永製薬ヘルスケア研究所
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Kawahara N
National Institute Of Health Sciences
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HAKAMATSUKA Takashi
Faculty of Pharmaceutical Sciences, Tokyo Science University
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SEKI Takahiro
School of Pharmaceutical Sciences, University of Shizuoka
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HAYASHI Tatsuo
Life Science Center, Lion Corporation
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NAGASHIMA Yoshio
Life Science Center, Lion Corporation
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Kuroyanagi Masanori
Fac. Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri Univ.
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Hakamatsuka T
Faculty Of Pharmaceutical Sciences Tokyo Science University
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川原 信夫
National Institute Of Health Sciences
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Kuroyanagi M
Department Of Life Sciences Faculty Of Life And Environmental Science Prefectural University Of Hiro
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Kuroyanagi Masanori
School Of Bioresources Hiroshima Prefectural University
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Kimura Mariko
Fac. Of Food Culture Dep. Of Nutrition Kurashiki Sakuyo Univ.
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Kawahara Nobuo
Division Of Pharmacognosy And Phytochemistry National Institute Of Health Sciences
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Nagashima Yoshio
Life Science Center Lion Corporation
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Seki Takahiro
School Of Pharmaceutical Sciences University Of Shizuoka
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Seki Takahiro
School Of Information Science Japan Advanced Institute Of Science And Tchnology Hokuriku
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Satake Motoyoshi
Division Of Pharmacognosy And Phytochemistry National Institute Of Health Science
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Hayashi Tatsuo
Life Science Center Lion Corporation
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Kawahara Nobuo
Tsukuba Div. Res. Center For Medicinal Plant Resources National Inst. Of Biomedical Innovation
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Satake Motoyoshi
Division Of Pharmacognosy And Phyochemistry National Institute Of Health Sciences
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