Tumor Antigen Occurs in N-Glycan of Royal Jelly Glycoproteins : Honeybee Cells Synthesize T-Antigen Unit in N-Glycan Moiety
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概要
- 論文の詳細を見る
In our previous paper (Kimura, Y., et al., Biosci. Biotechnol. Biochem., 67, 1852–1856, 2003), we found that a complex type N-glycans containing β1-3 galactose residue occurs on royal jelly glycoproteins. During structural analysis of minor components of royal jelly N-glycans, we found complex type N-glycans bearing both galactose and N-acetylgalactosamine residues. Detailed structural analysis of pyridylaminated oligosaccharide revealed that the newly found N-glycan had a complex type structure harboring a tumor marker (T-antigen) unit: Galβ1-3GalNAcβ1-4GlcNAcβ1-2Manα1-6 (Galβ1-3GalNAcβ1-4GlcNAcβ1-2Manα1-3) Manβ1-4GlcNAcβ1-4GlcNAc. To our knowledge, this may be the first report of the presence of the T-antigen unit in the N-glycan moiety of eucaryotic glycoproteins.
- 社団法人 日本農芸化学会の論文
- 2006-10-23
著者
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木村 吉伸
岡山大学農学部
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木村 吉伸
岡山大学 農
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Sugimoto Hiroyuki
Yamada Apiculture Center, Inc.
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YAMADA Hideo
Yamada Apiculture Center, Inc.
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KIMURA Yoshinobu
Department of Bioresources Chemistry, Faculty of Agriculture, Okayama University
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Yamada Hideyuki
SEIREN CO. LTD.
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木村 吉伸
Dep. Of Biofunctional Chemistry Graduate School Of Natural Sci. And Technol. Okayama Univ.
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MAEDA Megumi
Department of Hygiene, Kawasaki Medical School
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Kuroyanagi M
Fac. Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri Univ.
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木村 吉伸
岡山大学
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Kimura Mariko
Department Of Breast Oncology Aichi Cancer Center Hospital
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Kimura Mariko
Department Of Bioresources Chemistry Faculty Of Agriculture Okayama University
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Kimura M
Laboratory Of Biochemistry Faculty Of Agriculture Graduate School Kyushu University
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Maeda Megumi
Department Of Biofunctional Chemistry Division Of Bioscience Graduate School Of Natural Science And
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USHIJIMA Takayuki
Department of Biofunctional Chemistry, Division of Bioscience, Graduate School of Natural Science an
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HAMA Yoichiro
Department of Applied Biological Sciences, Faculty of Agriculture, Saga University
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OKIHARA Kiyoshi
Yamada Apiculture Center Inc.
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Kimura Yoshinobu
Department Of Agricultural Science Faculty Of Agriculture Okayama University
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Sugimoto Hiroyuki
Yamada Apiculture Center
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Yamada Hidenori
Department Of Bioengineering Science Faculty Of Engineering Okayama University
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Yamada H
Institute For Bee Products And Health Science Yamada Apiculture Center Inc.
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Kuroyanagi Masanori
Fac. Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri Univ.
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Yamada Hisami
Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University
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OKIHARA Kiyoshi
Institute for Bee Products and Health Science, Yamada Apiculture Center, Inc.
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Okihara K
Institute For Bee Products And Health Science Yamada Apiculture Center Inc.
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Hama Yoichiro
Department Of Applied Biochemistry And Food Science Saga University
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Kimura Yoshinobu
Department Of Biofunctional Chemistry Graduate School Of Natural Science And Technology Okayama Univ
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Kimura Mariko
Fac. Of Food Culture Dep. Of Nutrition Kurashiki Sakuyo Univ.
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Ushijima Takayuki
Department Of Biofunctional Chemistry Division Of Bioscience Graduate School Of Natural Science And
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Okihara Kiyoshi
Institute For Bee Products And Health Science Yamada Apiculture Center Inc.
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Maeda M
Department Of Biofunctional Chemistry Graduate School Of Natural Science And Technology Okayama Univ
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Yamada Hideo
Institute For Bee Products And Health Science Yamada Apiculture Center Inc.
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Yamada Hideo
Yamada Apiculture Center Inc.
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