Tumor Antigen Occurs in N-Glycan of Royal Jelly Glycoproteins : Honeybee Cells Synthesize T-Antigen Unit in N-Glycan Moiety

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概要

• 論文の詳細を見る

• In our previous paper (Kimura, Y., et al., Biosci. Biotechnol. Biochem., 67, 1852–1856, 2003), we found that a complex type N-glycans containing β1-3 galactose residue occurs on royal jelly glycoproteins. During structural analysis of minor components of royal jelly N-glycans, we found complex type N-glycans bearing both galactose and N-acetylgalactosamine residues. Detailed structural analysis of pyridylaminated oligosaccharide revealed that the newly found N-glycan had a complex type structure harboring a tumor marker (T-antigen) unit: Galβ1-3GalNAcβ1-4GlcNAcβ1-2Manα1-6 (Galβ1-3GalNAcβ1-4GlcNAcβ1-2Manα1-3) Manβ1-4GlcNAcβ1-4GlcNAc. To our knowledge, this may be the first report of the presence of the T-antigen unit in the N-glycan moiety of eucaryotic glycoproteins.

• 社団法人 日本農芸化学会の論文
• 2006-10-23

著者

• 木村 吉伸

  岡山大学農学部

• 木村 吉伸

  岡山大学 農

• Sugimoto Hiroyuki

  Yamada Apiculture Center, Inc.

• YAMADA Hideo

  Yamada Apiculture Center, Inc.

• KIMURA Yoshinobu

  Department of Bioresources Chemistry, Faculty of Agriculture, Okayama University

• Yamada Hideyuki

  SEIREN CO. LTD.

• 木村 吉伸

  Dep. Of Biofunctional Chemistry Graduate School Of Natural Sci. And Technol. Okayama Univ.

• MAEDA Megumi

  Department of Hygiene, Kawasaki Medical School

• Kuroyanagi M

  Fac. Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri Univ.

• 木村 吉伸

  岡山大学

• Kimura Mariko

  Department Of Breast Oncology Aichi Cancer Center Hospital

• Kimura Mariko

  Department Of Bioresources Chemistry Faculty Of Agriculture Okayama University

• Kimura M

  Laboratory Of Biochemistry Faculty Of Agriculture Graduate School Kyushu University

• Maeda Megumi

  Department Of Biofunctional Chemistry Division Of Bioscience Graduate School Of Natural Science And

• USHIJIMA Takayuki

  Department of Biofunctional Chemistry, Division of Bioscience, Graduate School of Natural Science an

• HAMA Yoichiro

  Department of Applied Biological Sciences, Faculty of Agriculture, Saga University

• OKIHARA Kiyoshi

  Yamada Apiculture Center Inc.

• Kimura Yoshinobu

  Department Of Agricultural Science Faculty Of Agriculture Okayama University

• Sugimoto Hiroyuki

  Yamada Apiculture Center

• Yamada Hidenori

  Department Of Bioengineering Science Faculty Of Engineering Okayama University

• Yamada H

  Institute For Bee Products And Health Science Yamada Apiculture Center Inc.

• Kuroyanagi Masanori

  Fac. Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri Univ.

• Yamada Hisami

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• OKIHARA Kiyoshi

  Institute for Bee Products and Health Science, Yamada Apiculture Center, Inc.

• Okihara K

  Institute For Bee Products And Health Science Yamada Apiculture Center Inc.

• Hama Yoichiro

  Department Of Applied Biochemistry And Food Science Saga University

• Kimura Yoshinobu

  Department Of Biofunctional Chemistry Graduate School Of Natural Science And Technology Okayama Univ

• Kimura Mariko

  Fac. Of Food Culture Dep. Of Nutrition Kurashiki Sakuyo Univ.

• Ushijima Takayuki

  Department Of Biofunctional Chemistry Division Of Bioscience Graduate School Of Natural Science And

• Okihara Kiyoshi

  Institute For Bee Products And Health Science Yamada Apiculture Center Inc.

• Maeda M

  Department Of Biofunctional Chemistry Graduate School Of Natural Science And Technology Okayama Univ

• Yamada Hideo

  Institute For Bee Products And Health Science Yamada Apiculture Center Inc.

• Yamada Hideo

  Yamada Apiculture Center Inc.

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