Evidence for new beta 1-3 galactosyltransferase activity involved in biosynthesis of unusual N-glycan harboring T-antigen in Apis mellifera
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概要
- 論文の詳細を見る
In a previous study (Y. Kimura et al., Biosci. Biotechnol Biochem., 70, 2583-2587, 2006), we found that new complex type N-glycans harboring Thomsen-Friedenreich antigen (Ga1 beta 1-3GalNAc) unit occur on royal jelly glycoproteins, suggesting the involvement of a new beta 1-3galactosyltransferase in the synthesis of the unusual complex type N-glycans. So far, such beta 1-3galactosyltransferase activity, which can transfer galactosyl residues with the beta 1-3 linkage to beta 1-4 GalNAc residues in N-glycan, has not been found among any eucaryotic cells. But using GalNAc(2)GlcNAc(2)Man(3)-GlcNAc(2)-PA as acceptor N-glycan, we detected the beta 1-3 galactosyltransferase activity in membrane fraction prepared from honeybee cephalic portions. This result indicates that honeybee expresses a unique beta 1-3 galactosyltransferase involved in biosynthesis of the unusual N-glycan containing a tumor related antigen in the hypopharyngeal gland.
- Japan Society for Bioscience, Biotechnology, and Agrochemistryの論文
- 2007-04-23
著者
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Kajiura Hiroyuki
The International Center for Biotechnology, Osaka University
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Fujiyama Kazuhito
The International Center for Biotechnology, Osaka University
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木村 吉伸
岡山大学農学部
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木村 吉伸
岡山大学 農
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Sugimoto Hiroyuki
Yamada Apiculture Center, Inc.
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YAMADA Hideo
Yamada Apiculture Center, Inc.
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KIMURA Yoshinobu
Department of Bioresources Chemistry, Faculty of Agriculture, Okayama University
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Yamada Hideyuki
SEIREN CO. LTD.
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木村 吉伸
Dep. Of Biofunctional Chemistry Graduate School Of Natural Sci. And Technol. Okayama Univ.
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木村 吉伸
岡山大学
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USHIJIMA Takayuki
Department of Biofunctional Chemistry, Division of Bioscience, Graduate School of Natural Science an
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HAMA Yoichiro
Department of Applied Biological Sciences, Faculty of Agriculture, Saga University
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OKIHARA Kiyoshi
Yamada Apiculture Center Inc.
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Kimura Yoshinobu
Department Of Agricultural Science Faculty Of Agriculture Okayama University
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Sugimoto Hiroyuki
Yamada Apiculture Center
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Fujiyama Kazuhito
The International Center For Biotechnology Osaka University
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Yamada Hidenori
Department Of Bioengineering Science Faculty Of Engineering Okayama University
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SAKAMURA Sho
Department of Biofunctional Chemistry, Division of Bioscience, Graduate School of Natural Science an
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HASHIMOTO Ken
Yamada Apiculture Center, Inc.
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Yamada Hisami
Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University
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OKIHARA Kiyoshi
Institute for Bee Products and Health Science, Yamada Apiculture Center, Inc.
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HASHIMOTO Ken
Institute for Bee Products and Health Science, Yamada Apiculture Center, Inc.
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Okihara K
Institute For Bee Products And Health Science Yamada Apiculture Center Inc.
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Hama Yoichiro
Department Of Applied Biochemistry And Food Science Saga University
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Kimura Yoshinobu
Department Of Biofunctional Chemistry Graduate School Of Natural Science And Technology Okayama Univ
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Ushijima Takayuki
Department Of Biofunctional Chemistry Division Of Bioscience Graduate School Of Natural Science And
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Fujiyama Kazuhito
The International Center For Biotechnology Osaka Univ. 2-1 Yamada-oka Suita Osaka 565-0871 Jpn
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Okihara Kiyoshi
Institute For Bee Products And Health Science Yamada Apiculture Center Inc.
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Sakamura Sho
Department Of Biofunctional Chemistry Division Of Bioscience Graduate School Of Natural Science And
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Yamada Hideo
Institute For Bee Products And Health Science Yamada Apiculture Center Inc.
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Yamada Hideo
Yamada Apiculture Center Inc.
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Kajiura Hiroyuki
The International Center For Biotechnology Osaka University
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Hashimoto Ken
Institute For Bee Products And Health Science Yamada Apiculture Center Inc.
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