Characterization of the Prr1 Response Regulator with Special Reference to Sexual Development in Schizosaccharomyces pombe(Biochemistry & Molecular Biology)

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概要

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• The histidine (His) -to-Aspartate (Asp) phosphorelay is a paradigm of intracellular signaling systems through protein phosphorylation in both prokaryotes and eukaryotes. The fission yeast Schizosaccharomyces pombe has three histidine kinases (Phk1/Mak2, Phk2/Mak3, and Phk3/Mak1), together with two response regulators (Mcs4 and Prr1). The results of recent extensive studies suggested that these His-to-Asp phosphorelay components are involved in oxidative stress responses through the transcriptional regulation of several scavenger genes for toxic free radicals. It was also suggested that they were somehow implicated in control of both the mitotic and meiotic cell proliferations. Among these S. pombe His-to-Asp phosphorelay components, however, the function of Prr1 is less clear. We here characterized a mutant, named prr1-D418N, specifying an altered Prr1 protein that presumably acts as a gain-of-function (or constitutive-active) mutant, with special reference to sexual development. The mutant cells showed a striking phenotype in that they underwent mating even in a nitrogen-sufficient medium, under which conditions the wild-type cells hardly did so. Furthermore, the mutant cells underwent mating very rapidly in a nitrogendeficient medium. Under anaerobic (or micro-aerobic) growth conditions, the wild-type cells were not capable of undergoing sexual development even in a nitrogendeficient medium. The prr1-D418N cells underwent mating efficiently under such anaerobic growth conditions. Taken these together, it was suggested that the function of Prr1 is closely linked to the well-characterized signaling pathways for induction of the sexual development, in a way that this response regulator regulates a critical step of the initiation of meiosis through activating the transcription of ste11^+, mam2^+, and mei2^+, in S. pombe.

• 社団法人日本農芸化学会の論文
• 2003-03-23

著者

• Ohmiya Ryusuke

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Yamada Hideyuki

  SEIREN CO. LTD.

• MIZUNO Takeshi

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• NAKAMICHI Norihito

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• Nakamichi Norihito

  Riken Yokohama Jpn

• Nakamichi Norihito

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• AIBA Hirofumi

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• Mizuno Takeshi

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Aiba H

  Nagoya Univ. Nagoya Jpn

• Aiba Hirofumi

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Aiba Hirofumi

  名古屋大学 農学部微生物学

• Aiba Hirofumi

  Laboratory Of Microbiology Faculty Of Agriculture Nagoya University

• YANADA Hisami

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• AOYAMA Keisuke

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• Ohmiya R

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Yamada Hidenori

  Department Of Bioengineering Science Faculty Of Engineering Okayama University

• Aiba H

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Yamada H

  Institute For Bee Products And Health Science Yamada Apiculture Center Inc.

• Aoyama K

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Yamada Hisami

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Mizuno Takeshi

  Laboratory Of Microbiology School Of Agriculture Nagoya University

• Aiba Hirofumi

  Laboratory Of Molecular Microbiology Graduate School Of Bioagricultural Sciences Nagoya University

• Yamada Hideo

  Institute For Bee Products And Health Science Yamada Apiculture Center Inc.

• NAKAMICHI Norihito

  Laboratory of Molecular and Functional Cenomics, School of Agriculture, Nagoya University

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