His-to-Asp Phosphorelay Circuitry for Regulation of Sexual Development in Schizosaccharomyces pombe(Biochemistry & Molecular Biology)

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概要

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• The fission yeast Schizosaccharomyces pombe has three histidine kinases (Phk1/Mak2, Phk2/Mak3, and Phk3/Mak1), and two response regulators (Mcs4 and Prr1). The results of recent extensive studies on the S. pombe His-to-Asp phosphorelay circuitry suggested that it is involved in oxidative stress responses through the transcriptional regulation of several scavenger genes for toxic free radicals. The functions of these histidine kinases have not yet been fully characterized. Here we characterize a homothallic (h^<90>) mutant lacking the genes for all the histidine kinases, with special reference to sexual development. Homothallic phk1/2/3Δ cells underwent mating precociously in a nitrogen-deficient medium. Surprisingly, the mutant cells underwent mating even in a nitrogen-sufficient medium, under which conditions wild-type cells did so rarely if at all. Under anaerobic (or microaerobic) growth conditions, wild-type cells did not undergo sexual development even in a nitrogen-deficient medium, but the homothallic phk1/2/3Δ cells mated efficiently. Oxidative reagents such as H_2O_2 induced sexual development in wild-type cells grown anaerobically. On the basis of these results, we propose the novel view that the S. pombe His-to-Asp phosphorelay, initiated by the Phk histidine kinases, is crucial for regulation of sexual development. This Phk-mediated signaling pathway is linked to the well-documented canonical pathway for induction of the sexual development, in that both converge at the initiation of meiosis through activation of ste11^+, mam2^+, and mei2^+ transcription.

• 社団法人日本農芸化学会の論文
• 2002-12-23

著者

• Ohmiya Ryusuke

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Yamada Hideyuki

  SEIREN CO. LTD.

• MIZUNO Takeshi

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• NAKAMICHI Norihito

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• YAMADA Hisami

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• Nakamichi Norihito

  Riken Yokohama Jpn

• Nakamichi Norihito

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• AIBA Hirofumi

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• Mizuno Takeshi

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Aiba H

  Nagoya Univ. Nagoya Jpn

• Aiba Hirofumi

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Aiba Hirofumi

  名古屋大学 農学部微生物学

• Aiba Hirofumi

  Laboratory Of Microbiology Faculty Of Agriculture Nagoya University

• AOYAMA Keisuke

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• Ohmiya R

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Yamada Hidenori

  Department Of Bioengineering Science Faculty Of Engineering Okayama University

• Aiba H

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Yamada H

  Institute For Bee Products And Health Science Yamada Apiculture Center Inc.

• Yamada Hisami

  Laboratory Of Microbiology School Of Agriculture Nagoya University

• Aoyama K

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Yamada Hisami

  Laboratory Of Molecular Microbiology School Of Agriculture Nagoya University

• Mizuno Takeshi

  Laboratory Of Microbiology School Of Agriculture Nagoya University

• Aiba Hirofumi

  Laboratory Of Molecular Microbiology Graduate School Of Bioagricultural Sciences Nagoya University

• Yamada Hideo

  Institute For Bee Products And Health Science Yamada Apiculture Center Inc.

• NAKAMICHI Norihito

  Laboratory of Molecular and Functional Cenomics, School of Agriculture, Nagoya University

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