New Leishmanicidal Stilbenes from a Peruvian Folk Medicine, Lonchocarpus nicou
スポンサーリンク
概要
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Two new stilbenes, 1 and 2, were isolated as leishmanicidal constituents from the methanolic extract of Lonchocarpus nicou leaves and stem, together with five known stilbenes and rotenoids. Their chemical structures were determined by spectral methods. Among them, the cis stilbene-type compounds 1 and 4 showed potent leishmanicidal activity (IC50: 5.5, 3.9 µg/mL), while the trans stilbene-type compounds 2 and 5, and rotenoids 6 and 7, showed moderate activities (IC50: 9.9, 12.8, 22.6, 19.6 µg/mL, respectively).
著者
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Kawahara Nobuo
Research Center for Medicinal Plant Resources, National Institute of Biomedical Innovation
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Sekita Setsuko
Kagawa Campus Tokushima Bunri University
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Fuchino Hiroyuki
Research Center For Medicinal Plant Resources National Institute Of Biomedical Innovation
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Satake Motoyoshi
Institute Of Environmental Science For Human Life Ochanomizu University
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Kiuchi Fumiyuki
Faculty Of Pharmaceutical Sciences Kanazawa University
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Wada Hiroshi
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Yamanaka Azusa
Faculty of Pharmaceutical Sciences, Tokyo University of Science
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Obu Akihiro
Faculty of Pharmaceutical Sciences, Tokyo University of Science
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Mori-Yasumoto Kanami
Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University
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Flores Diana
Scientific University of the South
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Palacios Olga
Tropical Medicine Institute "Daniel A. Carrión," National University of San Marcos
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Palacios Olga
Tropical Medicine Institute "Daniel A. Carrión," National University of San Marcos
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Wada Hiroshi
Faculty of Pharmaceutical Sciences, Tokyo University of Science
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