Martefragin A, a Novel Indole alkaloid Isolated from Red Alga, Inhibits Lipid Peroxidation
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概要
- 論文の詳細を見る
Martefragin A (1), a novel indole alkaloid, was isolated from a red alga, Martensia fragilis, by repeated column chromatography. The structure of 1 was elucidated on the basis of spectral analysis of its methyl ester (2), including ^1H- and ^<13>C-NMR, ^1H-^1H correlation spectroscopy (COSY), and ^<13>-^1H COSY. A single crystal X-ray analysis of the hydrochloride of 1 confirmed the assignment. Martefragin A (1) showed inhibitory activity on NADPH-dependent lipid peroxidation in rat liver microsomes. The IC_<50> values of 1,α-tocopherol and ascorbic acid were 2.8,87 and 200 μM, respectively.
- 公益社団法人日本薬学会の論文
- 1998-10-15
著者
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Kiuchi Fumiyuki
Faculty of Pharmacy, Keio University
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MATSUNAGA Takayuki
Toyama Prefectural Institute for Pharmaceutical Research
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TSUDA YOSHISUKE
Faculty of Pharmaceutical Sciences, Kanazawa University
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Kiuchi Fumiyuki
国立医薬品衛生研究所
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Kiuchi Fumiyuki
Faculty Of Pharmaceutical Sciences Kanazawa University
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Kiuchi Fumiyuki
Faculty Of Pharmaceutical Sciences Kanazawa University:(present Address)graduate School Of Pharmaceu
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Saito Haruo
Department Of Pharmaceutical Research Lead Chemical Co. Ltd.
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Saito H
Toyama Prefectural Institute For Pharmaceutical Research
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TAKAHASHI Satoshi
Toyama Prefectural Institute for Pharmaceutical Research
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Takahashi S
秋田県農林水産技術センター総合食品研究所
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HASEGAWA Chika
Toyama Prefectural Institute for Pharmaceutical Research
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SAITO Haruo
Toyama Prefectural Institute for Pharmaceutical Research
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FUJITA Daisuke
Toyama Prefectural Fisheries Research Institute
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Tsuda Yoshisuke
Faculty Of Pharmaceutical Sciences Kanazawa University
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Kiuchi Fumiyuki
Faculty Of Pharmaceutical Sciences Kanazawa University:(present Address)graduate School Of Pharmaceu
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