Anti-Invasive and Metastatic Activities of Evodiamine
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概要
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We have recently reported that evodiamine can suppress in vitro invasion and lung metastasis by colon 26-L5 carcinoma cells. To extend our study, we examine here the anti-invasive and metastatic effects of evodiamine on Lewis lung carcinoma (LLC) and B16-F1O melanoma in addition to colon 26-L5 carcinoma. Critical structures of evodiamine for the activities were also evaluated by comparison with compounds possessing structures similar to that of evodiamine. Evodiamine concentration-dependently inhibited the invasion of B16-F1O, LLC and colon 26-L5 cells with IC_50 values of 2.4μ_M, 4.8μ_M and 3.7μ_M, respectively. Pre-treatment of colon 26-L5 cells with evodiamine before inoculation into mice caused significant suppression of the liver metastasis as well as the lung metastasis. Lung metastasis by LLC is also inhibited significantly by pre-exposure to evodiamine. When the antimigratory activity of evodiamine was compared with that of evodiamine-like compounds, rutaecarpine lacking a methyl group at N-14 and a hydrogen at C-13b exhibited much less effect than evodiamine. In addition, reserpine, having β-configurated hydrogen at C-13b, inhibited tumor cell migration more potently than yohimbine, having α-configurated hydrogen at the same position. These results suggest that evodiamine may be useful as a leading compound for agents in tumor metastasis therapy. Also, the presence of a methyl group at N-14 and the configuration of hydrogen at C-13b may be responsible for the inhibitory activities of evodiamine.
- 公益社団法人日本薬学会の論文
- 2002-11-01
著者
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SAIKI Ikuo
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceuti
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Suzuki Hideyo
Toyama Prefectural Institute For Pharmaceutical Research
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Suzuki H
Toyama Prefectural Institute For Pharmaceutical Research
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Suzuki H
Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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MATSUNAGA Takayuki
Toyama Prefectural Institute for Pharmaceutical Research
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OGASAWARA Masaru
Toyama Prefectural Institute for Pharmaceutical Research
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TAKAHASHI Satoshi
Toyama Prefectural Institute for Pharmaceutical Research
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Takahashi S
秋田県農林水産技術センター総合食品研究所
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Saiki Ikuo
Department Of Pathogenic Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceutica
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Suzuki Hideyo
Toyama Prefectural Inst. For Pharmaceutical Res. Toyama Jpn
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Saiki Ikuo
Department Of Bioscience Institute Of Natural Medicine Toyama University
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