Isolation of the Antiulcer Compound in Essential Oil from the Leaves of Cryptomeria japonica
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概要
- 論文の詳細を見る
Essential oil from the leaves of Tateyamasugi (Cryptomeria japonica) exhibited strong inhibitory activity on ulceration induced by HCl/ethanol, HCl/aspirin, water-immersion stress and pylorus-ligation. We separated the antiulcer compounds from cedar essntial oil by use of distillation and chromatography. As a result, terpinen-4-ol, a monoterpene, and elemol, a sesquiterpene, were isolated as active compounds. The antiulcer activity of the former was more potent than that of the latter. Terpinen-4-ol was a mixture of optical isomers and each possessed potent antiulcer activity. Secretion of gastric juice and output of acid and pepsin activity were lowered by terpinen-4-ol.These results suggest that terpinen-4-ol isolated from cedar essential oil could be a valuable antiulcer agent.
- 公益社団法人日本薬学会の論文
- 2000-05-01
著者
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Suzuki Hideyo
Toyama Prefectural Institute For Pharmaceutical Research
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Suzuki H
Toyama Prefectural Institute For Pharmaceutical Research
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Suzuki H
Department Of Medicinal Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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MATSUNAGA Takayuki
Toyama Prefectural Institute for Pharmaceutical Research
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Saito Haruo
Department Of Pharmaceutical Research Lead Chemical Co. Ltd.
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Saito H
Toyama Prefectural Institute For Pharmaceutical Research
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Takahashi S
秋田県農林水産技術センター総合食品研究所
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HASEGAWA Chika
Toyama Prefectural Institute for Pharmaceutical Research
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KAWASUJI Toru
Toyama Prefectural Institute for Pharmaceutical Research
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SAITO Haruo
Toyama Prefectural Institute for Pharmaceutical Research
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SAGIOKA Tadashi
Toyama Forestry and Forest Products Research Center
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TAKAHASHI Rihei
Toyama Forestry and Forest Products Research Center
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TSUKAMOTO Hideko
Toyama Forestry and Forest Products Research Center
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MORIKAWA Toshiyuki
Yasuhara Chemical Co., Ltd.,
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AKIYAMA Takeshi
Yasuhara Chemical Co., Ltd.,
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Akiyama Takeshi
Yasuhara Chemical Co. Ltd.
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Suzuki Hideyo
Toyama Prefectural Inst. For Pharmaceutical Res. Toyama Jpn
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Tsukamoto H
Toyama Forestry And Forest Products Research Center
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Morikawa Toshiyuki
Yasuhara Chemical Co. Ltd.
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Akiyama Takeshi
Faculty Of Technology Tokyo University Of Agriculture And Technology
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