EFFECT OF N-FORMYL-L-METHIONYL-L-LEUCYL-L-PHENYLALANINE AND ITS ANALOGUES ON BLOOD PRESSURE
スポンサーリンク
概要
- 論文の詳細を見る
Effects of N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP), the synthetic chemotactic peptide, and its analogues on blood pressure were investigated in the rabbit, rat, mouse, dog, cat and guinea pig. The administration of FMLP (5μg/kg i.v.) induced the depressor effect in the rabbit but no effect was observed in the other animal species. The only peptide which showed a similar effect as FMLP was N-formyl-L-methionyl-L-methionyl-L-phenylalanine (FMMP) among the peptides relating to FMLP. Tachyphylaxis was observed in the hypotensive action induced by the two peptides.
- 公益社団法人日本薬学会の論文
著者
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SAITO Haruo
Department of Radiological Technology, School of Health Sciences, Faculty of Medicine
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SAKAI Takeshi
Department of Physics and Research Center for the Early Universe, The University of Tokyo
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KITAGAWA HARUO
Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba
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NAMINOHIRA SHIGERU
Department of Toxicology, School of Pharmacy, Hokuriku University
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Saito Haruo
Department Of Pharmaceutical Research Lead Chemical Co. Ltd.
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Kitagawa Haruo
Laboratory Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Chiba University:division Of Anal
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Kitagawa Haruo
Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University
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Kitagawa Haruo
Laboratory Of Biochemical Pharmacology And Blotoxicology Faculty Of Pharmaceutical Sciences Chiba Un
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Kitagawa Haruo
Analytical And Metabolic Research Laboratories And Biological Research Laboratories Sankyo Co. Ltd.:
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MATSUO MOTOYA
Department of Toxicology, School of Pharmacy, Hokuriku University
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HIRATA ARTHUR
Department of Microbiology, University of Kansas
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Naminohira Shigeru
Department Of Toxicology School Of Pharmacy Hokuriku University
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Matsuo Motoya
Department Of Toxicology School Of Pharmacy Hokuriku University
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Hirata Arthur
Department Of Microbiology University Of Kansas
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Kitagawa H
Laboratory Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Chiba University:division Of Anal
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Saito Haruo
Department Of Toxicology School Of Pharmacy Hokuriku University
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Sakai Takeshi
Department Of Toxicology School Of Pharmacy Hokuriku University
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Sakai Takeshi
Department Of Pathology Niigata Prefectural Central Hospital
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Sakai Takeshi
Department Of Electrical Engineering College Of Engineering University Of Osaka Prefecture
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Saito Haruo
Department Of Drug Evaluation And Toxicological Sciences Faculty Of Pharmaceutical Sciences Chiba Un
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NAMINOHIRA Shigeru
Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences, Chiba University
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KITAGAWA Haruo
Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University
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SAKAI TAKESHI
Department of Chemical Engineering, Gunma University
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