STIMULATORY EFFECT OF CYANIDE ON ANILINE p-HYDROXYLATION IN RAT LIVER MICROSOMES

スポンサーリンク

概要

• 論文の詳細を見る

• Enhancement of aniline hydroxylation was observed by the addition of cyanide in rat liver microsomes. The enhancing effect of cyanide on aniline hydroxylation activity was also observed in rabbit liver microsomes, but not in guinea pig liver microsomes. Aniline stimulated the reoxidation of reduced nicotinamide adenine dinucleotide (NADH)-reduced cytochrome b_5. The stimulation of cytochrome b_5 reoxidation by aniline was most remarkable in liver microsomes from desaturase-induced rats followed by that from fed and fasted rats. The increment in cytochrome b_5 reoxidation by aniline in all groups of rats was inhibited by the simultaneous addition of cyanide, However, the stimulatory effect of cyanide on aniline hydroxylation in fasted rat was not different from that observed in desaturase-induced rat. In addition, the effect of cyanide on aniline hydroxylation was suggested to be reversible.

• 公益社団法人日本薬学会の論文

著者

• KAMATAKI TETSUYA

  Department of Pharmacology, School of Medicine, Keio University

• KITAGAWA HARUO

  Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba

• Kamataki Tetsuya

  Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University

• KITADA MITSUKAZU

  Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences, Chiba University

• Kitada Mitsukazu

  Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University

• Kitagawa Haruo

  Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University

• KITAGAWA Haruo

  Department of Biochemical Pharmacology and Biotoxicology, Faculty of Pharmaceutical Sciences, Chiba University

• KAMATAKI Tetsuya

  Department of Analytical Bio chemistry, School of Pharmacy, Hokkaido University

関連論文

• MACROMOLECULAR BINDING OF CARCINOGENIC/MUTAGENIC N- HYDROXYARYLAMINES THROUGH O-ACETYLATION PATHWAY
• MECHANISM OF MUTATION AND METABOLIC ACTIVATION OF NITRO-, NITROSO-, HYDROXYLAMINO-COMPOUNDS IN NITRO-COMPOUNDS RESISTANT MUTANTS OF AMES TESTAR STRAIN (TA98NR, TA98/1,8-DNP_6)
• CYP2A6 and the plasma level of 5-chloro-2,4-dihydroxypyridine are determinants of the pharmacokinetic variability of tegafur and 5-fluorouracil, respectively, in Japanese patients with cancer given S-1
• ROLE OF GROWTH HORMONE ON THE EXPRESSION OF SEX-SPECIFIC FORMS OF CYTOCHROME P-450,P-450-MALE AND P-450-FEMALE
• STUDIES ON SEX-SPECIFIC FORMS OF CYTOCHROME P-450 IN MALE AND FEMALE RATS
• "B-9 Factors Regulating CYP1A1 Induction in Adult Rabbit Livers.
• ATTENUATION OF ASPIRIN ANALGESIA BY CALCIUM LOADING IN HEALTHY SUBJECTS
• THE EFFECTS OF ASPIRIN AND ITS METABOLITE, SALICYLIC ACID, ON CULTURED RAT EMBRYO
• ACETYLSALICYLIC ACID INDUCED FETALTOXICITY AND DRUG METABOLISM
• POTENTIATION OF EPN-INDUCED INHIBITION OF LIVER MICROSOMAL CARBOXYLESTERASE BY NAD IN VITRO
• TOXICOLOGICAL SIGNIFICANCE OF A FORM OF CYTOCHROME P-450 HIGHLY PURIFIED FROM LIVER MICROSOMES OF PCBTREATED RATS : CATALYTIC AND IMMUNOCHEMICAL EXAMINATIONS OF A HIGH SPIN FORM OF CYTOCHROME P-448
• The Role of Glutathione in the Activation and Detoxication of a Naturally Occurring Mutagen-Carcinogen, Trp-P-2 (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology)
• MECHANISMS INVOLVED IN THE COVALENT BINDING OF A TRYPTOPHAN-PYROLYSATE PROMUTAGEN, TRP-P-2,TO DNA
• STUDIES ON CYTOCHROME P-450 RESPONSIBLE FOR THE OCCURRENCE OF SEX DIFFERENCE OF DRUG METABOLISM IN THE RAT
• A SENSITIVE METHOD FOR THE DETERMINATION OF BIPHENYL HYDROXYLASE ACTIVITY AND IT'S TOXICOLOGICAL APPLICATION
• MECHANISMS OF METABOLIC ACTIVATION OF A TRYPTOPHAN PYROLYSATE, 3-AMINO-1-METHYL-5H-PYRIDO [4,3-b] INDOLE
• PURIFICATION AND PROPERTIES OF CYTOCHROME P-450 AND NADPH-CYTOCHROME C (P-450) REDUCTASE FROM MICROSOMES OF HUMAN LIVERS
• STUDIES ON THE METABOLIC ACTIVATION AND THE MECHANISM OF TOXICITY OF DRUGS V. REDUCTION OF N-HYDROXY DERIVATIVE OF AN AROMATIC AMINE, 2-ACETYLAMINOFLUORENE BY CYTOCHROME P-450 (The 6th Meeting for the Study of Toxic Effect)
• DEGRADATION OF CYTOCHROME P-450 ASSOCIATED WITH METABOLIC ACTIVATION OF CARBON TETRACHLORIDE (The 5th Meeting for the Study of Toxic Effect)
• STIMULATORY EFFECT OF CYANIDE ON ANILINE p-HYDROXYLATION IN RAT LIVER MICROSOMES
• Enhancement in vivo of drug oxidations following administration of benzphetamine,acetone,metyrapone and dimethylsulfoxide
• Enhancement of NADPH-dependent lipid peroxidation activity by ethylenediaminetetraacetic acid(EDTA) in the presence of ferrous ion in rabbit liver microsomes
• EFFECTS OF DIIOSPROPYL-1, 3-DITHIOL-2-YLIDENE MALONATE (NKK-105) ON ACUTE TOXICITY OF VARIOUS DRUGS AND HEAVY METALS.
• MECHANISM OF ANTI-PLATELET AGGREGATING ACTION OF DILAZEP
• Effect of Grapefruit Juice on the Urinary 6β-hydroxycortisol/cortisol Ratio
• EFFECT OF LIPID PEROXIDATION ON COVALENT BINDING OF ACTIVE METABOLITE OF ACETAMINOPHEN TO LIVER MICROSOMAL MACROMOLECULES IN SEVERAL ANIMAL SPECIES
• PROTECTIVE ROLE OF COMPONENTS IN CELL CYTOSOL AGAINST ACETAMINOPHEN-INDUCED HEPATOTOXICITY (The Fourth Meeting for the Study of Toxic Effect)
• 118. METABOLISM AND HEPATOTOXICITY OF ACETAMINOPHEN (The Third Meeting for the Study of Toxic Effect)
• COMPARISON OF EFFECTS OF ACETAMINOPHEN ON LIVER MICROSOMAL DRUG METABOLISM AND LIPID PEROXIDATION IN RATS AND MICE
• Further Studies on the Persistence of Neonatal Androgen Imprinting on Sex-Specific Cytochrome P-450, Testosterone and Drug Oxidations
• Effects of Hypophysectomy and Growth Hormone Treatment on Sex-Specific Forms of Cytochrome P-450 in Relation to Drug and Steroid Metabolisms in Rat Liver Microsomes
• MULTIPLICITY AND REGULATION OF HEPATIC MICROSOMAL CARBOXYLESTERASE IN RATS
• THE INVOLVEMENT OF CYTOCHROME P-448 AND P-450 IN NADH-DEPENDENT O-DEMETHYLATION OF p-NITROANISOLE IN RAT LIVER MICROSOMES
• ENHANCEMENT IN VIVO OF DRUG OXIDATIONS FOLLOWING ADMINISTRATION OF BENZPHETAMINE, ACETONE, METYRAPONE AND DIMETHYLSULFOXIDE
• ENHANCEMENT OF NADPH-DEPENDENT LIPID PEROXIDATION ACTIVITY BY ETHYLENE-DIAMINETETRAACETIC ACID (EDTA) IN THE PRESENCE OF FERROUS ION IN RABBIT LIVER MICROSOMES
• STIMULATIVE EFFECTS OF CHELATING AGENTS, 2, 2-BIPYRIDINE AND 1, 10-PHENANTHROLINE, ON LIPID PEROXIDATION IN RAT LIVER MICROSOMES
• INDIVIDUAL DIFFERENCES IN THE OCCURRENCE OF A LIPID PEROXIDATION INHIBITOR IN RAT LIVER SOLUBLE FRACTION
• DIFFERENCES IN THE EFFECT OF EPHEDRINE ISOMERS ON BLOOD PRESSURE IN RATS
• METABOLIC STUDIES ON METIAZINIC ACID I ABSORPTION, DISTRIBUTION, EXCRETION AND METABOLISM IN RATS AND RABBITS
• EFFECT OF N-FORMYL-L-METHIONYL-L-LEUCYL-L-PHENYLALANINE AND ITS ANALOGUES ON BLOOD PRESSURE
• INFLUENCE OF MATERNAL DRUG METABOLISM ON THE FETAL TOXICITY INDUCED BY ACETYLSALICYLIC ACID
• EFFECTS OF VARIOUS COMPOUNDS ON LIPID PEROXIDATION MEDIATED BY DETERGENT-SOLUBILIZED RAT LIVER NADPH-CYTOCHROME C REDUCTASE
• LIPID PEROXIDATION ACTIVITY MEDIATED BY NADPH-CYTOCHROME C REDUCTASE PURIFIED FROM RABBIT LIVER MICROSOMES
• INHIBITION BY SKF 525-A OF 7-ETHOXYCOUMARIN O-DEETHYLATION IN MICROSOMAL AND THE RECONSTITUTED MONOOXYGENASE SYSTEMS FROM PCB-TREATED RAT LIVERS
• EFFECTS OF LYOPHILIZATION AND STORAGE OF RAT LIVER MICROSOMES ON ACTIVITY OF ANILINE HYDROXYLASE, CONTENTS OF CYTOCHROME b5 AND CYTOCHROME P-450 AND ANILINE-INDUCED P-450 DIFFERENCE SPECTRUM
• STUDIES ON THE ULTRASTRUCTURAL DISTRIBUTION OF H3-DIMETACRINE IN RAT CEREBRAL CORTEX
• GLUTATHIONE DEPLETION BY ANILINE ANALOGS IN VITRO ASSOCIATED WITH LIVER MICROSOMAL CYTOCHROME P-450
• EFFECT OF LYOPHILIZATION AND STORAGE OF LIVER 9, 000 × g SUPERNATANT FRACTION ON THE METABOLISM OF IMIPRAMINE IN SEVERAL SPECIES OF ANIMALS
• METABOLIC ACTIVATION AND INACTIVATION BY CYTOCHROME P-450 (Biochemical background for mechanisms of toxicity)
• THE APPARENT LOSS OF CYTOCHROME P-450 ASSOCIATED WITH METABOLIC ACTIVATION OF CARBON TETRACHLORIDE
• Stimulation of microsomal drug oxidation activities by incorporation into microsomes of purified NADPH-cytochrome c (P-450) reductase.
• Inhibition by cyanide of drug oxidations in rat liver microsomes.
• Cause of decrease of ethylmorphine N-demethylase activity by lipid peroxidation in microsomes from the rat, guinea pig and rabbit.
• COMPARISON OF N-OXIDATION AND N-DEMETHYLATION OF DIMETHYLANILINE IN HUMAN LIVER
• Plasma glutathione S-transferase in carbon tetrachrolide treated rats and its association to hepatic cytosolic isozymes.
• Drug oxidation activities of horseradish peroxidase, myoglobin and cytochrome P-450cam reconstituted with synthetic hemes.

もっと見る 閉じる

スポンサーリンク