TOXICOLOGICAL SIGNIFICANCE OF A FORM OF CYTOCHROME P-450 HIGHLY PURIFIED FROM LIVER MICROSOMES OF PCBTREATED RATS : CATALYTIC AND IMMUNOCHEMICAL EXAMINATIONS OF A HIGH SPIN FORM OF CYTOCHROME P-448

スポンサーリンク

概要

• 論文の詳細を見る
• 公益社団法人日本薬学会の論文

著者

• KATO Ryuichi

  Department of Biology,Graduate School of Science,Osaka University

• YAMAZOE YASUSHI

  Department of Pharmacology, School of Medicine, Keio University

• KAMATAKI TETSUYA

  Department of Pharmacology, School of Medicine, Keio University

• Yamazoe Y

  Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho

• Yamazoe Yasushi

  Department Of Pharmacology School Of Medicine Keio University:department Of Analytical Biochemistry

• Kato Ryuichi

  Department Of Pharmacology School Of Medicine Keio University

• Kato Ryuichi

  Department Of Biology Graduate School Of Science Osaka University

• Yamazoe Yasushi

  Department Of Pharmacology School Of Medicine Keio University

• MAEDA KAORI

  Department of Pharmaceutics, Hoshi University

• Kato Ryuichi

  Dept. Of Pharmacol. School Of Med. Keio Univ.

• Kamataki T

  Hokkaido Univ. Sapporo Jpn

• Kamataki Tetsuya

  Department Of Pharmacology School Of Medicine Keio University:department Of Analytical Biochemistry

• Kamataki Tetsuya

  Department Of Biochemical Pharmacology Faculty Of Pharmaceutical Sciences Chiba University

• Kamataki Tetsuya

  Division Of Analytical Biochemistry Faculty Of Pharmaceutical Sciences Hokkaido University

• Kamataki Tetsuya

  Department Of Pharmacology School Of Medicine Keio University

• Maeda Kaori

  Department Of Pharmaceutics Hoshi University

• Yamazoe Yasushi

  Division Of Drug Metabolism And Molecular Toxicology Graduate School Of Pharmaceutical Sciences Toho

• Kamataki Tetsuya

  Lab. Drug Metab. Fac. Pharm. Sci. Hokkaido University

• KAMATAKI Tetsuya

  Department of Analytical Bio chemistry, School of Pharmacy, Hokkaido University

• YAMAZOE Yasushi

  Department of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University

関連論文

• Changes in Cerebral Oxygen Saturation and Blood Flow During Hypoxic Gas Ventilation Therapy in HLHS and CoA/IAA Complex With Markedly Increased Pulmonary Blood Flow
• Crystallization and Preliminary X-Ray Crystallographic Studies of Thermus thermophilus HB8 MutM Protein Involved in Repairs of Oxidative DNA
• ヒトP450分子種の HepG2 細胞における複数同時発現 : 組換えアデノウイルスを用いたP450再構成系
• ヒト薬物動態関連遺伝子の発現に対するHNF4αの寄与をsiRNA発現アデノウイルスを用いて解析する
• MACROMOLECULAR BINDING OF CARCINOGENIC/MUTAGENIC N- HYDROXYARYLAMINES THROUGH O-ACETYLATION PATHWAY
• MECHANISM OF MUTATION AND METABOLIC ACTIVATION OF NITRO-, NITROSO-, HYDROXYLAMINO-COMPOUNDS IN NITRO-COMPOUNDS RESISTANT MUTANTS OF AMES TESTAR STRAIN (TA98NR, TA98/1,8-DNP_6)
• Modulation of Ethanol-Mediated CYP2E1 Induction by Clofibrate and L-Carnitine in Rat Liver
• Molecular Cloning and Characterization of Rat ST1B1 and Human ST1B2 cDNAs, Encoding Thyroid Hormone Sulfotransferases
• Formation of 2-Amino-3-methylimidazo[4,5-f]quinoline- and 2-Amino-3, 8-dimethylimidazo[4,5-f]quinoxaline-sulfamates by cDNA-expressed Mammalian Phenol Sulfotransferases
• 327 Isolation and expression of hamster acetyltransferase genes, AT-A and AT-B
• CLONING, EXPRESSION, AND FUNCTIONAL CHARACTERIZATION OF RAT AND HUMAN PHENOL SULFOTRANSFERASES
• RAT LIVER SULFOTRANSFERASE ACTIVATING CARCINOGENIC HYDROXYMETHYL-ARENES : ITS PROPERTIES AND SEQUENCE ANALYSIS OF cDNA
• CYP2A6 and the plasma level of 5-chloro-2,4-dihydroxypyridine are determinants of the pharmacokinetic variability of tegafur and 5-fluorouracil, respectively, in Japanese patients with cancer given S-1
• Bile Acid-Induced Elevated Oxidative Stress in the Absence of Farnesoid X Receptor(Biochemistry)
• Hydroxysteroid sulfotransferase (SULT2A) の発現はFXRにより抑制的に調節される
• Bile acid sulfates as a possible early marker of liver toxicity(Drug metabolism, Proceedings of the 32nd Annual Meeting)
• Expression of hydroxysteroid sulfotransferase involved in protection against bile acid-induced hepatotoxicity(Drug metabolism, Proceedings of the 32nd Annual Meeting)
• Protection from liver toxicity induced by lithocholic acid-feeding : Involvement of cyp3a and hydroxysteroid sulfotransferase(Drug metabolism, Proceedings of the 32nd Annual Meeting)
• Bile acid-induced liver toxicity and nuclear receptor FXR (LIVER/DIGESTIVE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
• Thalidomide-induced suppression of embryo fibroblast proliferation requires CYP1A1-mediated activation.(GENERAL SESSION BY ORAL PRESENTATION)(DRUG METABOLISM)
• O11-03 Relative importance of maternal and embryonic microsomal epoxide hydrolase in 7, 12-dimethylbenz[a] anthracene : induced developmental toxicity
• Mechanism of 7,12-Dimethylbenz[α]anthracene-Induced Immunotoxicity: Role of Metabolic Activation at the Target Organ
• O-26 Difference between Spleen and Thymus in 7, 12-Dimethylbenz[a]anthracene-lnduced lmmunotoxicity.(Proceedings of the 27th Annual Meeting)
• Construction of Several Human-derived Stable Cell Lines Displaying Distinct Profiles of CYP3A4 Induction
• Differences in Transactivation between Rat CYP3A1 and Human CYP3A4 Genes by Human Pregnane X Receptor
• A Hydroxysteroid Sulfotransferase, St2b2, Is a Skin Cholesterol Sulfotransferase in Mice
• Adenovirus Vector-Mediated Reporter System for In Vivo Analyses of Human CYP3A4 Gene Activation
• Alteration of Hepatic Sulfation by Endotoxin
• Enzymatic Characterization of Human Cytosolic Sulfotransferases : Identification of ST1B2 as a Thyroid Hormone Sulfotransferase
• Bacterial Expression and Functional Characterization of a Rat Thyroid Hormone Sulfotransferase, ST1B1
• Molecular Cloning, Expression, and Enzymatic Characterization of Rabbit Hydroxysteroid Sulfotransferase AST-RB2 (ST2A8)^1
• MECHANISM OF THE CHANGES IN HEPATIC DRUG METABOLIZING ENZYMES IN DIABETIC STATES
• REGULATION AND CHARACTERIZATION OF STEROID 6β-HYDROXYLASE IN RAT LIVERS
• B24 DRUG-INDUCED LOSS OF CONSTITUTIVE CYTOCHROME P-450 IN RAT LIVERS AND THE MECHANISM
• ROLE OF GROWTH HORMONE ON THE EXPRESSION OF SEX-SPECIFIC FORMS OF CYTOCHROME P-450,P-450-MALE AND P-450-FEMALE
• STUDIES ON SEX-SPECIFIC FORMS OF CYTOCHROME P-450 IN MALE AND FEMALE RATS
• RNA干渉法を用いたヒト肝チトクロムP450遺伝子の転写活性化に及ぼすPXRの寄与の評価
• Selective Suppressions of Human CYP3A Forms, CYP3A5 and CYP3A7, by Troglitazone in HepG2 Cells
• Molecular Cloning and Expression of an Amine Sulfotransferase cDNA: A New Gene Family of Cytosolic Sulfotransferases in Mammals^1
• Metabolic nuclear receptor and chemical-induced liver toxicity(Proceedings of the 32nd Annual Meeting)
• "B-9 Factors Regulating CYP1A1 Induction in Adult Rabbit Livers.
• An Aspartate Aminotransferase from an Extremely Thermophilic Bacterium, Thermus thermophilus HB8^1
• Clinical course linkage among different priapism subtypes : Dilemma in the management strategies
• Crystal Structure of Thermus thermophilus HB8 UvrB Protein, a Key Enzyme of Nucleotide Excision Repair
• Cloning and characterization of the radA gene from a hyperthermophilic archaeon Pyrobaculum islandicum.
• Development of an In Vitro System Detecting Pro-embryotoxin
• Inhibitory Potential of Herbal Medicines on Human Cytochrome P450-Mediated Oxidation : Properties of Umbelliferous or Citrus Crude Drugs and Their Relative Prescriptions
• Inhibitory Effect of Natural Furanocoumarins on Human Microsomal Cytochrome P450 3A Activity
• Rivulobirin E and Rivulotririn C from Pleurospermum rivulorum
• Quantitative Analysis of Three-dimensional Fatigue Fracture Surface Reconstructed by Stereo Matching Method
• Automated Image Processing and Analysis of Fracture Surface Patterns Formed during Creep Crack Growth in Austenitic Heat-Resisting Steels with Different Microstructures
• STEREOSELECTIVE HYDROXYLATION OF MEPHENYTOIN IN HUMAN LIVERS : CLONING AND EXPRESSION OF MEPHENYTOIN HYDROXYLASE cDNAS IN YEASTS AND THE GENETIC POLYMORPHISM
• S-5 CURRENT TOPICS OF SPECIES SPECIFICITY IN DRUG TOXICITY-METABOLIC ASPECT
• Changes in Cerebral Oxygen Saturation and Blood Flow During Hypoxic Gas Ventilation Therapy in HLHS and CoA/IAA Complex With Markedly Increased Pulmonary Blood Flow
• TOXICOLOGICAL SIGNIFICANCE OF A FORM OF CYTOCHROME P-450 HIGHLY PURIFIED FROM LIVER MICROSOMES OF PCBTREATED RATS : CATALYTIC AND IMMUNOCHEMICAL EXAMINATIONS OF A HIGH SPIN FORM OF CYTOCHROME P-448
• The Role of Glutathione in the Activation and Detoxication of a Naturally Occurring Mutagen-Carcinogen, Trp-P-2 (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology)
• MECHANISMS INVOLVED IN THE COVALENT BINDING OF A TRYPTOPHAN-PYROLYSATE PROMUTAGEN, TRP-P-2,TO DNA
• Metabolic activation of amino acid-pyrolysates and its relation to mutagenicity
• STUDIES ON CYTOCHROME P-450 RESPONSIBLE FOR THE OCCURRENCE OF SEX DIFFERENCE OF DRUG METABOLISM IN THE RAT
• A SENSITIVE METHOD FOR THE DETERMINATION OF BIPHENYL HYDROXYLASE ACTIVITY AND IT'S TOXICOLOGICAL APPLICATION
• MECHANISMS OF METABOLIC ACTIVATION OF A TRYPTOPHAN PYROLYSATE, 3-AMINO-1-METHYL-5H-PYRIDO [4,3-b] INDOLE
• PURIFICATION AND PROPERTIES OF CYTOCHROME P-450 AND NADPH-CYTOCHROME C (P-450) REDUCTASE FROM MICROSOMES OF HUMAN LIVERS
• STUDIES ON THE METABOLIC ACTIVATION AND THE MECHANISM OF TOXICITY OF DRUGS V. REDUCTION OF N-HYDROXY DERIVATIVE OF AN AROMATIC AMINE, 2-ACETYLAMINOFLUORENE BY CYTOCHROME P-450 (The 6th Meeting for the Study of Toxic Effect)
• DEGRADATION OF CYTOCHROME P-450 ASSOCIATED WITH METABOLIC ACTIVATION OF CARBON TETRACHLORIDE (The 5th Meeting for the Study of Toxic Effect)
• STIMULATORY EFFECT OF CYANIDE ON ANILINE p-HYDROXYLATION IN RAT LIVER MICROSOMES
• Efficacy of a 14-day course of oral ciprofloxacin therapy for acute uncomplicated pyelonephritis
• Nerve injury-related erectile dysfunction following nerve-sparing radical prostatectomy : A novel experimental dissection model
• Alteration of glial cell line-derived neurotrophic factor family receptor alpha-2 mRNA expression and its co-expression with neuronal nitric oxide synthase in pelvic ganglia following unilateral cavernous nerve injury
• Outcome analysis for conservative management of Peyronie's disease
• Erectile dysfunction following nerve-sparing radical retropubic prostatectomy and its treatment with sildenafil
• Erosion of a penile prosthesis due to an indwelling urethral catheter as a late complication
• The correlation between penile tumescence measured by the erectometer and penile rigidity by the RigiScan
• Genetic Polymorphism of Human Cytochrome P450 Involved in Drug Metabolism
• A Case of Chronic Infantile Neurological Cutaneous Articular (CINCA) Syndrome with Marked Growth Disturbance
• Interferon-γ modulate Ia antigen expression on thymic reticuloepithelial cells in New Zealand mice
• FATTY ACID DEPENDENT-ENZYME STIMULATED ACTIVATION OF CARCINOGENIC ARYLAMINES TO THE DEOXYRIBONUCLEIC ACID BINDING PRODUCTS
• Fractal Dimension of Grain-boundary Fracture for Characterization of High-temperature Fracture in Heat-resistant Alloys
• Quantitative Evaluation of the Impact Fracture Surfaces of SS400 Steel by the Three-dimensional Geometrical Analysis
• Fractal Analysis of Fracture Surfaces in Materials Crept at High Temperatures or Fatigued by Repeated Bending
• Change in the Fracture Surface Pattern in the Fracture Process of SUS631 Stainless Steel Fatigued by Repeated Bending
• Characterization of Insulin-Dependent Diabetes Mellitus Induced by a New Variant (DK-27) of Encephalomyocarditis Virus in DBA/2 Mice
• TOXICOKINETICS:ITS SIGNIFICANCE AND PRACTICAL PROBLEMS
• Further Studies on the Persistence of Neonatal Androgen Imprinting on Sex-Specific Cytochrome P-450, Testosterone and Drug Oxidations
• Effects of Hypophysectomy and Growth Hormone Treatment on Sex-Specific Forms of Cytochrome P-450 in Relation to Drug and Steroid Metabolisms in Rat Liver Microsomes
• THEBAINE METABOLITES IN THE URINE OF RHESUS MONKEYS
• METABOLIC FATE OF FEPRAZONE
• THE INVOLVEMENT OF CYTOCHROME P-448 AND P-450 IN NADH-DEPENDENT O-DEMETHYLATION OF p-NITROANISOLE IN RAT LIVER MICROSOMES
• ENHANCEMENT IN VIVO OF DRUG OXIDATIONS FOLLOWING ADMINISTRATION OF BENZPHETAMINE, ACETONE, METYRAPONE AND DIMETHYLSULFOXIDE
• ENHANCEMENT OF NADPH-DEPENDENT LIPID PEROXIDATION ACTIVITY BY ETHYLENE-DIAMINETETRAACETIC ACID (EDTA) IN THE PRESENCE OF FERROUS ION IN RABBIT LIVER MICROSOMES
• STIMULATIVE EFFECTS OF CHELATING AGENTS, 2, 2-BIPYRIDINE AND 1, 10-PHENANTHROLINE, ON LIPID PEROXIDATION IN RAT LIVER MICROSOMES
• INDIVIDUAL DIFFERENCES IN THE OCCURRENCE OF A LIPID PEROXIDATION INHIBITOR IN RAT LIVER SOLUBLE FRACTION
• EFFECTS OF α- AND β-ADRENERGIC BLOCKERS ON CHLORPROMAZINE-INDUCED ELEVATION OF PLASMA GLUCOSE AND CYCLIC AMP IN FED MICE
• EFFECT OF CHLORPROMAZINE ON INSULIN RELEASE IN MICE: COMPARISON BETWEEN IN VIVO AND IN VITRO
• AN UNUSUAL METABOLITE OF TESTOSTERONE BY CYTOCHROME P-450
• Anthralin, a Non-TPA Type Tumor Promoter, Synergistically Enhances Phorbol Ester-Caused Prostaglandin E2 Release from Primary Cultured Mouse Epidermal Cells
• Inhibitory Regulation of Serum Factor(s)-Caused Ornithine Decarboxylase Induction by the Protein Kinase C System in A431 Human Epidermoid Carcinoma Cells
• Mechanism of Thyroxine-induced Increase in Steroid Δ4-Reductase Actiyity in Male Rats
• INHIBITION BY SKF 525-A OF 7-ETHOXYCOUMARIN O-DEETHYLATION IN MICROSOMAL AND THE RECONSTITUTED MONOOXYGENASE SYSTEMS FROM PCB-TREATED RAT LIVERS
• METABOLIC ACTIVATION AND INACTIVATION BY CYTOCHROME P-450 (Biochemical background for mechanisms of toxicity)
• THE APPARENT LOSS OF CYTOCHROME P-450 ASSOCIATED WITH METABOLIC ACTIVATION OF CARBON TETRACHLORIDE

もっと見る 閉じる

スポンサーリンク