EFFECTS OF α- AND β-ADRENERGIC BLOCKERS ON CHLORPROMAZINE-INDUCED ELEVATION OF PLASMA GLUCOSE AND CYCLIC AMP IN FED MICE
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概要
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The subcutaneous administration of chlorpromazine (CPZ) caused a dose response increase in plasma glucose and cyclic AMP levels in fed male mice. Hexamethonium abolished the elevation of both plasma glucose and cyclic AMP. Propranolol did not inhibit the elevation of plasma glucose but inhibited the increase of plasma cyclic AMP. In contrast, phentolamine and yohimbine completely suppressed the elevation of plasma glucose but not that of plasma cyclic AMP. These results indicate that the hyperglycemia due to CPZ was mediated through the stimulation of α-adrenoceptor and on the contrary CPZ increased plasma cyclic AMP through the stimulation of β-adrenoceptor and that the increase in plasma glucose induced by CPZ was independent of the activation of adenylate cyclase and the increased plasma cyclic AMP. In addition, in contrast to phentolamine and yohimbine, phenoxybenzamine was ineffective to prevent the hyperglycemia induced by CPZ. Moreover, a higher dose of dihydroergotamine was required to inhibit the hyperglycemia.
- 社団法人 日本薬理学会の論文
著者
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KATO Ryuichi
Department of Biology,Graduate School of Science,Osaka University
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NAKADATE Teruo
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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Kato Ryuichi
Department Of Biology Graduate School Of Science Osaka University
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Nakadate Teruo
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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MURAKI Takamura
Department of Pharmacology, Tokyo Women's Medical University, School of Medicine
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Muraki Takamura
Department Of Pharmacology Tokyo Women's Medical College
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NAKADATE Teruo
Department of Pharmacology, School of Medicine, Keio University
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MURAKI TAKAMURA
Department of Dermatology, School of Medicine, Keio University
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