Effects of Morphine and Naloxone on Serum LH, FSH and Prolactin Levels and on Hypothalamic Content of LH-RF in Proestrous Rats
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概要
- 論文の詳細を見る
Proestrus surges of serum LH, FSH and prolactin (PRL) were significantly reduced when morphine HCl (50 and 10mg/kg) was administered to 4-day cycling rats just prior to the proestrous critical period. The inhibitory effect ofmorphine was reversed by naloxone, a morphine antagonist, at the dose which had no effect on the proestrus surges of serum LH, FSH or PRL. The hypothalmic LH-RF content of proestrous rats at 1800 hr (during the proestrus surge) was not significantly different from that at 1400 hr (before the surge) and was not affected by pretreatment with morphine or naloxone. Our results suggest that naloxone reverses the antiovulatory effect of morphine by antagonizing the inhibitory effect of morphine on preovulatory surges of gonadotropins or PRL.
- 社団法人 日本内分泌学会の論文
著者
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Muraki Takamura
Department Of Pharmacology Tokyo Women's Medical College
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Makino Tsunehisa
Department Of Obstetrics And Gynecology Center For Growth And Reproductive Medicine Tokai University
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Tokunaga Yukiko
Department Of Pharmacology School Of Medicine Keio University
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Makino Tsunehisa
Department Of Obstetrics And Gynecology
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Makino Tsunehisa
Department Of Obstetrics & Gynecology School Of Medicine Tokai University
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MAKINO TSUNEHISA
Department of Gynecology and Obstetrics, School of Medicine, Keio University
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