Effect of Tazarotene, an Acetylenic Retinoid, on Human Dermal Fibroblast
スポンサーリンク
概要
- 論文の詳細を見る
The inhibitory effect of tazarotene, an acetylenic retinoid, on human dermal fibroblast in vitro was compared to that of all-trans-retinoic acid. The proliferation of fibroblasts was inhibited by both retinoids at the concentration of 1 μM after 5 days of culture. Synthesis of DNA and collagen was inhibited by both retinoids concentration-dependently up to 10 μM, although tazarotene was weaker in the inhibition of collagen synthesis. These results suggest the possible usefulness of tazarotene in the treatment of fibrotic diseases.
- 社団法人 日本薬理学会の論文
著者
-
OGAWA Akira
Department of Neurosurgery, Iwate Medical University School of Medicine
-
YOSHINAGA Tomoo
Department of Physiology and Biomechanics National Institute of Fitness and Sports
-
YOSHIOKA Toshimasa
Department of Pharmacology, Tokyo Women's Medical University, School of Medicine
-
MURAKI Takamura
Department of Pharmacology, Tokyo Women's Medical University, School of Medicine
-
KAWASHIMA Makoto
Department of Dermatology, Tokyo Women's Medical University School of Medicine
-
Uchida Yoko
Department Of Pharmacology Tokyo Women's Medical University
-
Ogawa Akira
Department Of Biochemistry Gunma University Graduate School Of Medicine
-
Kawashima Makoto
Department Of Dermatology Tokyo Women's Medical University
-
Muraki T
Department Of Pharmacology Tokyo Women's Medical University School Of Medicine
-
Muraki Takamura
Department Of Pharmacology Tokyo Women's Medical College
-
MAEGUCHI Mizue
Department of Dermatology, Tokyo Women's Medical University
-
Maeguchi Mizue
Department Of Dermatology Tokyo Women's Medical University
-
Yoshioka Toshimasa
Department Of Pharmacology Tokyo Women's Medical University School Of Medicine
-
Yoshioka Toshimasa
Department Of Medical Eudcation Tokyo Women's Medical University School Of Medicine
-
Ogawa Akira
Department Of Pharmacology Tokyo Women's Medical University
-
Ogawa Akira
Department Of Applied Chemistry Graduate School Of Engineering The University Of Tokyo
-
Uchida Yoko
Department Of Environmental Sciences Faculty Of Education And Human Sciences Yokohama National Unive
-
Yoshioka Toshimasa
Department Of Medical Education Tokyo Women's Medical University
-
Kawashima Makoto
Department Of Dermatology Tokyo Women's Medical College
-
MURAKI TAKAMURA
Department of Dermatology, School of Medicine, Keio University
関連論文
- Direct Relief of Levodopa-Induced Dyskinesia by Stimulation in the Area Above the Subthalamic Nucleus in a Patient With Parkinson's Disease : Case Report
- X-ray Spectra from Weakly Ionized Linear Copper Plasma
- Castleman's Disease of the Retroperitoneum : With Special Reference to IgG4-Related Disorder
- PJ-193 What Levels of Plasma BNP are Related to Increased Risk of Onset of Cardiovascular Events in the General Population?(PJ033,Preventive Medicine/Epidemiology/Education 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese
- OJ-176 Prehypertension is an Indicator of High Prevalence of Albuminuria, and a Predictor of Cardiovascular Events in the General Population(OJ30,Hypertension, Clinical (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Ci
- OJ-091 Is Metabolic Syndrome a Useful Predictor for Cardiovascular Events and Death in the Rural Population?(OJ16,Metabolic Syndrome (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- X-ray Spectra from a Brass-target Plasma Triode
- Enhanced K-edge Angiography Utilizing Tantalum Plasma X-ray Generator in Conjunction with Gadolinium-Based Contrast Media
- Variations in Cerium X-ray Spectra and Enhanced K-Edge Angiography
- Histochemical Responses of Human Soleus Muscle Fibers to Long-Term Bedrest with or without Countermeasures
- Cyclin D1 Protein Overexpression in Extramedullary Plasmacytoma : A Clinicopathologic Study of 11 Cases
- Measurement of Cerium X-ray Spectra Using a Cerium Oxide Powder Filter and Enhanced K-edge Angiography
- X-ray Spectra from a Characteristic X-ray Generator with a Molybdenum Tube
- Clinicopathological Study of Unilateral Multiple Breast Cancer
- Atypical finding of brain Tc-99m-ECD SPECT imaging in herpes simplex encephalitis
- Hemorrhage and Abnormal Veins in Acoustic Neurinoma : MR Findings
- Angular dependence of x-ray spectra from a demountable x-ray tube with a copper target
- Cysteinyl Leukotriene Receptor Antagonists Inhibit Tumor Metastasis by Inhibiting Capillary Permeability
- K-edge digital angiography using a flat panel detector with a pixel size of 50μm
- Molecular Characterization of the Mouse mtprd Gene, a Homologue of Human TPRD: Unique Gene Expression Suggesting Its Critical Role in the Pathophysiology of Down Syndrome^1
- Identification and Cloning of a Novel cDNA Belonging to Tetratricopeptide Repeat Gene Family from Down Syndrome-Critical Region 21q22.2
- Accumulation of Negative Ions in Hollow-Type Electron Cyclotron Resonance CF_4 Plasma Column
- ガンマ線照射後器官培養された豚眼毛様体上皮におけるアポトーシス
- Ganglioneurocytoma : Distinctive variant of central neurocytoma
- Desmoplastic cerebral astrocytoma of infancy intermingling with atypical glial cells
- Possible involvement of T cell co-stimulation in pustulosis palmaris et plantaris via the induction of inducible co-stimulator in chronic focal infections
- PJ-656 Albuminuria is an Independent Predictor for the Onset of Cardiovascular Events in the General Population(Kidney/Renal circulation-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Malignant Intracranial Meningioma With Spinal Metastasis : Case Report
- Application of Fenestrated Aneurysm Clip for Incomplete Clamping of the Common Carotid Artery During Carotid Endarterectomy : Technical Note
- Choice of Posterior Subtemporal Transtentorial Approach for Tumor Resection in Deep Anteromedial Superior Cerebellum
- Rupture of a Concomitant Unruptured Cerebral Aneurysm Within 2 Weeks of Surgical Repair of a Ruptured Cerebral Aneurysm
- Lipomatous Meningioma With Concomitant Acute Subdural Hematoma
- Fusion of Magnetic Resonance Angiography and Magnetic Resonance Imaging for Surgical Planning for Meningioma
- Endarterectomy for Mild Cervical Carotid Artery Stenosis in Patients With Ischemic Stroke Events Refractory to Medical Treatment
- Brain Retraction Technique Using Gelatin Sponge in the Subtemporal Approach
- Treatment of Ruptured Spontaneous Saccular Aneurysm in the Central Artery of the Middle Cerebral Artery Using Bypass Surgery Combined With Trapping
- Improved Geometric Distortion in Coronal Diffusion-weighted and Diffusion Tensor Imaging Using a Whole-brain Isotropic-voxel Acquisition Technique at 3 Tesla
- Meningioma in the Posterior Fossa Without Dural Attachment : Case Report
- Complete Neck Clipping of Internal Carotid-Posterior Communicating Artery Aneurysms Using Bayonet-Shaped Aneurysm Clips : Technical Note
- Urgent Endarterectomy Using Pretreatment With Free Radical Scavenger, Edaravone, and Early Clamping of the Parent Arteries for Cervical Carotid Artery Stenosis With Crescendo Transient Ischemic Attacks Caused by Mobile Thrombus and Hemodynamic Cerebral Is
- Persistent Falcine Sinus Associated With Obstruction of the Superior Sagittal Sinus Caused by Meningioma : Case Report
- Trapping and Vascular Reconstruction for Ruptured Fusiform Aneurysm in the Proximal A_1 Segment of the Anterior Cerebral Artery : Case Report
- Stevens-Johnson Syndrome Associated With Intravenous Acetazolamide Administration for Evaluation of Cerebrovascular Reactivity : Case Report
- Recovery Process of Immediate Prolonged Posttraumatic Coma Following Severe Head Injury Without Mass Lesions
- Ruptured Vertebral Artery Dissecting Aneurysm Followed by Spontaneous Acute Occlusion and Early Recanalization
- Quantitative Analysis of Magnetic Resonance Imaging Susceptibility Artifacts Caused by Neurosurgical Biomaterials : Comparison of 0.5, 1.5, and 3.0 Tesla Magnetic Fields
- Soft-Decision Decoding of Low-Density Parity-Check Codes for Hard-Detected Optical Communication Signals
- Comparison of Multiple Access Schemes in Multibeam Non-GEO Satellite Communication Systems
- The Real-Time Parallel Video Decoder Considered on the Complexity and Delay of Error Correcting Decoding
- BER Analysis for Multi-Carrier DS CDMA with Multi-Rate Traffic (Special Section on Multi-dimensional Mobile Information Networks)
- Generation of Sets of Sequences Suitable for Multicode Transmission in Quasi-Synchronous CDMA Systems
- Autopsy findings of patients with urological neoplasms
- Error Correcting Capability of Constant Amplitude Coding for Orthogonal Multi-Code CDMA Systems (Special Section on Information Theory and Its Applications)
- A Constant Amplitude Coding for Orthogonal Multi-Code CDMA Systems (Special Section on Spread Spectrum Techniques and Applications)
- Non-coherent Reception of M-ary Spread-Spectrum Signals in the Presence of Carrier Frequency Offset
- The Role of Rho and Rho-Dependent Kinase in Serotonin-Induced Contraction Observed in Bovine Middle Cerebral Artery
- OJ-092 Predictive Value of Plasma B-type Natriuretic Peptide for Ischemic Stroke in a Community-based Male Population of Northern Japan(Cerebrovascular circulation / Stroke-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Early Revascularization in a Patient With Perfusion Computed Tomography/Diffusion-Weighted Magnetic Resonance Imaging Mismatch Secondary to Acute Vertebral Artery Occlusion
- High-field MRI of the Central Nervous System : Current Approaches to Clinical and Microscopic Imaging
- Urothelial Cancer Metastasized into Mediastinal Benign Neurilemmonia: A Case Report
- Combining Time-resolved and Single-phase 3D Techniques in Contrast-enhanced Carotid MR Angiography
- Self-efficacy achieved through problem-based learning tutorial
- Information and Signal Processing for Sensor Networks(Wide Band Systems)
- Trochlear and Abducens Nerve Neurinomas Accompanied by a Cerebellopontine Angle Meningioma : Case Report
- Changes in Renal Osteodystrophy and Skeletal Complications after Renal Transplantation in Children
- Energy-storable Dye-sensitized Solar Cells with Interdigitated Nafion/Polypyrrole-Pt Comb-like Electrodes
- Sonic Analysis for Detection of Cervical and Intracranial Vascular Disease
- Bowen's disease on the sole associated with human papillomavirus type 31
- Japanese version of Cutaneous Body Image Scale : Translation and validation
- Increased expression of CD208 (DC-LAMP) in epidermal keratinocytes of psoriatic lesions
- Transient crossed cerebellar diaschisis secondary to cerebral hyperperfusion following carotid endarterectomy
- Immunohistochemical localization of protease-activated receptors in cerebral and testicular arterioles of rats : their dependence on arteriole size and organ-specificity
- Preparation of One Structural Isomer of Tetra-substituted Phthalocyanine, 1, 8, 15, 22-Tetra(3'-pentoxy)phthalocyanine, and a Crystal Structure of Its Nickel(II) Complex
- Evaluation of the newly established acne severity classification among Japanese and Korean dermatologists
- Establishment of grading criteria for acne severity
- AlGaAs/GaAs Laser Diodes with GaAs Islands Active Regions on Si Grown by Droplet Epitaxy
- AlGaAs/GaAs Laser Diodes with GaAs Islands Active Regions on Si Substrates Grown by Droplet Epitaxy
- Growth Velocity and Nutritional Status in Young Children Undergoing Continuous Ambulatory Peritoneal Dialysis
- Effect of S-Ethylisothiourea, a Putative Inhibitor of Inducible Nitric Oxide Synthase, on Mouse Skin Vascular Permeability
- Characteristics of cerebral β amyloid deposition in four non-demented patients in their forties with a high apolipoprotein E ε4 allele frequency
- The immunophenotype of perivascular cells in the human brain
- Lone Survival after Resection for Lung Metastasis of Malignant Peripheral Nerve Sheath Tumor in Neurofibromatosis 1
- The Effect of Acute Cold Exposure and Norepinephrine on Uncoupling Protein Gene Expression in Brown Adipose Tissue of Monosodium Glutamate-Obese Mice
- Effect of Tazarotene, an Acetylenic Retinoid, on Human Dermal Fibroblast
- EFFECT OF INTRACEREBROVENTRICULAR ADMINISTRATION OF CHLORPROMAZINE ON THE SERUM LEVEL OF FREE FATTY ACIDS IN RATS
- Businessmen's perspectives concerning thier experiences with people with dementia and information about dementia ; Survey on the actual situation of participants in a lecture on dementia care
- EFFECTS OF MORPHINE ON THE LEVEL OF THE FREE FATTY ACIDS IN THE SERUM OF RATS
- EFFECTS OF CHLORPROMAZINE ON LIPOLYSIS IN BROWN AND WHITE ADIPOSE TISSUES OF COLD-EXPOSED RATS
- K-ras Codon 12 Mutation and Horizontal Growth of Colorectal Cancer
- p53 Overexpression and K-ras Codon 12 Mutations in Submucosal Invasive Colorectal Cancer
- Histochemical Study on Enzymatic Activity of the Hair cells of the Vestibular Organs in Guinea Pigs, especially Histochemical Reaction in Fresh Non-frozen Cristae Ampullares and Maculae
- EFFECTS OF α- AND β-ADRENERGIC BLOCKERS ON CHLORPROMAZINE-INDUCED ELEVATION OF PLASMA GLUCOSE AND CYCLIC AMP IN FED MICE
- A Case of Symptomatic Primary HIV Infection
- Minute Glioma Identified by 3.0 Tesla Magnetic Resonance Spectroscopy : Case Report
- Cutaneous polyarteritis nodosa : A report of 16 cases with clinical and histopathological analysis and a review of the published work
- Effect of standard medication on quality of life of patients with atopic dermatitis
- The role of protease-activated receptors on the intracellular calcium ion dynamics of vascular smooth muscles, with special reference to cerebral arterioles
- Two Cases of Desmoplastic Trichoepithelioma
- INVOLVEMENT OF CENTRAL CHOLINERGIC SYSTEM IN DECREASE OF SERUM FATTY ACIDS AFTER INTRACEREBROVENTRICULAR ADMINISTRATION OF CHLORPROMAZINE
- A Series of Polymorphs with Different Colors in Fluorescent 2,5-Diamino-3,6-dicyanopyrazine Dyes