The Effect of Acute Cold Exposure and Norepinephrine on Uncoupling Protein Gene Expression in Brown Adipose Tissue of Monosodium Glutamate-Obese Mice

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概要

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• Abnormal regulation of mitochondrial uncoupling protein (UCP) gene expression was studied in brown adipose tissue (BAT) of monosodium glutamate (MSG)-induced obese mice. UCP mRNA levels in control mice increased markedly after acute cold exposure; however, MSG-obese mice showed an impaired response. In contrast, an injection of norepinephrine (NE) induced a comparable increase in UCP mRNA levels in control and MSG-obese mice. These results suggest that the impairment in the cold-induced increase in UCP mRNA is due to a deficient sympathetic input to BAT and/or to a diminished response of BAT to endogenous NE, which constitutes the mechanism of impaired thermoregulation in obese mice in a cold environment.

• 社団法人 日本薬理学会の論文
• 1998-07-01

著者

• OGAWA Akira

  Department of Neurosurgery, Iwate Medical University School of Medicine

• YOSHINAGA Tomoo

  Department of Physiology and Biomechanics National Institute of Fitness and Sports

• TSUKAHARA Fujiko

  Department of Pharmacology, Tokyo Women's Medical University, School of Medicine

• OHBA Ken-ichi

  Department of Pharmacology, Tokyo Women's Medical University, School of Medicine

• YOSHIOKA Toshimasa

  Department of Pharmacology, Tokyo Women's Medical University, School of Medicine

• MURAKI Takamura

  Department of Pharmacology, Tokyo Women's Medical University, School of Medicine

• Uchida Yoko

  Department Of Pharmacology Tokyo Women's Medical University

• Ogawa Akira

  Department Of Biochemistry Gunma University Graduate School Of Medicine

• Ohba Ken-ichi

  Third Department Of Medicine Higashi General Hospital

• Ohba Ken-ichi

  Department Of Health Administration School Of Allied Health Sciences Kitasato University

• Ohba K

  Miyazaki Medical Coll. Miyazaki Jpn

• Muraki T

  Department Of Pharmacology Tokyo Women's Medical University School Of Medicine

• Muraki Takamura

  Department Of Pharmacology Tokyo Women's Medical College

• Yoshioka Toshimasa

  Department Of Pharmacology Tokyo Women's Medical University School Of Medicine

• Yoshioka Toshimasa

  Department Of Medical Eudcation Tokyo Women's Medical University School Of Medicine

• Tsukahara F

  Department Of Pharmacology Tokyo Women's Medical University School Of Medicine

• Ogawa Akira

  Department Of Pharmacology Tokyo Women's Medical University

• Ogawa Akira

  Department Of Applied Chemistry Graduate School Of Engineering The University Of Tokyo

• Uchida Yoko

  Department Of Environmental Sciences Faculty Of Education And Human Sciences Yokohama National Unive

• Ohba Ken-ichi

  Department Of Environmental Occupational Health And Toxicology School Of Allied Health Sciences Graduate School Of Medical Sciences Kitasato University

• Yoshioka Toshimasa

  Department Of Medical Education Tokyo Women's Medical University

• TSUKAHARA Fujiko

  Department of Pharmacology, Tokyo Women's Medical College

• MURAKI TAKAMURA

  Department of Dermatology, School of Medicine, Keio University

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