Study on blood levels of luteinizing hormone beta subunit and LH-releasing factor in pregnant women.

概要

論文の詳細を見る
The hypothalamo-pituitary function during pregnancy was investigated by analysing blood levels of Luteinizing Hormone Releasing Factor (LH-RF) and LH-beta subunit. A specific and sensitive radioimmunoassay which can detect as small as 300 femtogram of LH-RF per tube was developed. This re-vealed that plasma LH-RF concentrations were 1.0 ± 0.14pg/ml (mean ± S.E.) at follicular phase (n=17) and 1.1 ± 0.19pg/ml at luteal phase (n=8), whereas LH-RH was detectable in only 3 out of 20 samples from pregnant women and mean values were significantly decreased to 0.4 ± 0.02pg/ml. Simi-larly serum hLH beta levels were 438.56 ± 49.30 ng/ml at follicular phase (n=33), 632.71 ± 75.09ng/ml at mid-cycle (n=21) and 258.55 ± 46.84ng/ml at luteal phase (n=20), respectively. The levels of this hormone were also markedly decreased to 11.81 ± 0.95ng/ml during pregnancy (n=129).The data indicate that the hypothalamo-pituitary function, in terms of the hormones measured in this study, is lowered during pregnancy, presumably by the influences of placental hormones.
The Keio Journal of Medicineの論文