EFFECTS OF ANGIOTENSING ON THE MOTILITY OF HUMAN SPERM
スポンサーリンク
概要
- 論文の詳細を見る
The effects of angiotensins on the motility of highly washed human sperm were examined by multiple exposure photography system. The addition of low doses (0.1-10 ng/ml) of angiotensin II (AT II) stimulated the forward velocity of sperm without increasing the percentage of motility. On the contrary, high concentration (1.0 μg/ml) of AT II suppressed the motility. The direct effect of angiotensin I (AT I) on the motility was observed under the presence of SQ 14225,a specific inhibitor of angiotensin I converting enzyme (ACE). AT I (0.1-100 ng/ml) gave no influence on the motility, whereas that of high dose (1.0 μg/ml) suppressed the motility in the same manner as the corresponding dose of AT II. The action of AT II on the motility was completely suppressed under the coexistense of saralasin, a specific antagonist anainst AT II. This fact indicated that the action of AT II on the sperm appeared through the specific receptor on sperm.
- 公益社団法人日本薬学会の論文
著者
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Oshio Shigeru
Department of Hygiene Chemistry, Ohu University School of Pharmaceutical Sciences
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Oshio Shigeru
Department Of Biology University Of Tokyo
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KANEKO Satoru
Department of Physics, Ochanomizu University
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IIZUKA Rihachi
Department of Obstetrics and Gynecology School of Medicine, Keio University
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Iizuka Rihachi
Department Of Obstetrics And Gynecology School Of Medicine Keio University
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Kaneko Satoru
Department Of Obstetrics And Gynecology School Of Medicine Keio University
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KOBAYASHI TOSHIFUMI
Department of Obstetrics and Gynecology, School of Medicine, Keio University
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Kobayashi Toshifumi
Department Of Obstetrics And Gynecology School Of Medicine Keio University
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Kobayashi Toshifumi
Department Of Obstetrics And Gynecology Keio University School Of Medicine
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Kaneko Satoru
Department Of Obstetrics And Gynecology Ichikawa General Hospital Tokyo Dental College
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Kaneko Satoru
Department of Innovative and Engineered Materials, Tokyo Institute of Technology, Yokohama 226-8503, Japan
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IIZUKA RIHACHI
Department of Obstetrics & Gynecology, School of Medicine, Keio University
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