Detection of Immunoreactive Human Placental Oxytocin and its Contractile Effect on the Uterine Muscle
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概要
- 論文の詳細を見る
Freshly obtained human placentas from various periods of gestation were quantitatively analysed for their immunoreactive oxytocin (OT) content and its biological activity was examined in a Magnus apparatus by utilizing rat uterus.<BR>The mean values for placental immunoreactive OT per gram tissue increased from the first to the second trimester, maintaining its high level to term. The total content of placental OT also increased continually from the beginning of pregnancy to term. Blood levels of estrogen stimulated neurophysin (ESN) and OT were concomitantly enhanced through gestation. Placental extract and synthetic OT showed similar peaks in the elution pattern of ion-exchange chromatography through a carboxymethyl cellulose column. Synthetic OT and placental extract induced marked uterine contraction in diestrous rats. However placental extract previously incubated with OT antiserum failed to induce this effect.<BR>Though detection of immunoreactive OT by immunoassay alone does not provide definite identification of pituitary and placental OT, the present study suggests that placental immunoreactive OT could have a contracting effect on the uterine muscle.
- 社団法人 日本内分泌学会の論文
著者
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Iizuka Rihachi
Department Of Obstetrics And Gynecology School Of Medicine Keio University
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Ishii Kunio
Department Of Molecular Pharmacology Kitasato University School Of Pharmaceutical Sciences
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NAKAZAWA Kazumi
Department of Obstetrics and Gynecology, Fujita Health University Banbuntane Houtokukai Hospital
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Makino T
Keio Univ. Tokyo Jpn
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Makino Tsunehisa
Department Of Obstetrics And Gynecology
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HAGINIWA ICHIGEN
Department of Obstetrics and Gynecology, and Department of Pharmacology, School of Medicine
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NAKAYAMA AKIHIKO
Department of Obstetrics and Gynecology, and Department of Pharmacology, School of Medicine
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Makino Tsunehisa
Department Of Obstetrics & Gynecology School Of Medicine Tokai University
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MAKINO TSUNEHISA
Department of Gynecology and Obstetrics, School of Medicine, Keio University
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MAKINO TSUNEHISA
Department of Obstetrics and Gynecology, and Department of Pharmacology, School of Medicine
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NAKAZAWA KAZUMI
Department of Obstetrics and Gynecology, and Department of Pharmacology, School of Medicine
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ISHII KUNIO
Department of Obstetrics and Gynecology, and Department of Pharmacology, School of Medicine
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