Involvement of Bradykinin in Trypsin-Induced Urinary Bladder Contraction in Cyclophosphamide-Treated Rats
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概要
- 論文の詳細を見る
Protease-activated receptor-2 (PAR-2) is activated by serine proteases, such as trypsin and mast cell tryptase. Previous studies have demonstrated that both trypsin and PAR-2 activating peptide contract isolated rat urinary bladder preparations, however, the mechanisms are not fully understood. In the present study, we examined the role of bradykinin in contractions induced by trypsin and the PAR-2 agonist 2-furoyl-LIGRL-NH2 in urinary bladders isolated from control or cyclophosphamide (CYP)-induced cystitis rats. The contractile effects of trypsin were significantly greater in the preparations obtained from CYP-treated rats than in those from controls. The bradykinin B2 receptor antagonist Hoe 140 did not affect trypsin-induced contractions in control rat bladders, whereas it significantly reduced the contractile effects of trypsin on bladders from CYP-treated rats. On the other hand, Hoe 140 failed to affect contractions induced by the PAR-2 agonist 2-furoyl-LIGRL-NH2. These results suggest that the actions of trypsin on urinary bladders in cystitis rats are partly exerted through stimulation of bradykinin B2 receptor in a PAR-2-independent manner. This mechanism seems to be involved in the enhancement of trypsin-induced bladder contractions observed after induction of cystitis with CYP in rats.
- 公益社団法人 日本薬学会の論文
著者
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Sakamoto Kenji
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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MORI ASAMI
Department of Pediatrics, Shiga University Medical Science
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Nakahara Tsutomu
Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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Ishii Kunio
Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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Shimizu Naoko
Department Of Ophthalmology Chubu Rosai Hospital
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Mori Asami
Department Of Pediatrics Shiga University Medical Science
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Nakahara Tsutomu
Dep. Of Molecular Pharmacology School Of Pharmaceutical Sciences Kitasato Univ.
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Nakahara Tsutomu
Department Of Developmental Physiology Institute For Comprehensive Medical Sciences Fujita-gakuen Un
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Tsuda Yo
Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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Sakamoto Kenji
Department Of Advanced Material Science Faculty Of Engineering Kagawa University
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Ishii Kunio
Department Of Molecular Pharmacology Kitasato University School Of Pharmaceutical Sciences
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Mori Asami
Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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Mori Asami
Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences
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Shimizu Naoko
Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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Sakamoto Kenji
Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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