Vasodilator Effects of Ibudilast on Retinal Blood Vessels in Anesthetized Rats
スポンサーリンク
概要
- 論文の詳細を見る
Ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-α]pyridine) is clinically used as a cerebral vasodilator in Japan. However, the effects of ibudilast on retinal blood vessels have not been fully examined. The aim of this study, therefore, was to examine the effects of ibudilast on retinal blood vessels in rats in vivo. Male Wistar rats (8 to 10 weeks old) were anesthetized with thiobutabarbital (120 mg/kg, intraperitoneally (i.p.)). Retinal vascular images were captured with a fundus camera system for small animals, and the diameter of retinal blood vessels was measured. Ibudilast (0.1 and 1 mg/kg, intravenously (i.v.)) elicited a sustained increase in the diameter of retinal blood vessels and heart rate without altering systemic blood pressure. The effects of ibudilast were significantly reduced by treatment with the nonselective cyclooxygenase inhibitor indomethacin (5 mg/kg, i.p.). These results suggest that ibudilast dilates retinal blood vessels through cyclooxygenase-dependent mechanisms in rats in vivo.
- 日本薬学会の論文
著者
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Sakamoto Kenji
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Sakamoto K
National Inst. Materials Sci. Ibaraki Jpn
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MORI ASAMI
Department of Pediatrics, Shiga University Medical Science
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NOGUCHI Masahiro
Department of Radiology, Sakura Hospital
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Nakahara Tsutomu
Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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Ishii Kunio
Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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Sakamoto Kenji
Research Institute Of Marine Bioresources Fukuyama University
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Mori Asami
Department Of Pediatrics Shiga University Medical Science
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Nakahara Tsutomu
Department Of Developmental Physiology Institute For Comprehensive Medical Sciences Fujita-gakuen Un
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Sakamoto Kenji
Department Of Advanced Material Science Faculty Of Engineering Kagawa University
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Ishii Kunio
Department Of Molecular Pharmacology Kitasato University School Of Pharmaceutical Sciences
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Noguchi Masahiro
Department Of Industrial Chemistry Faculty Of Engineering Ibaraki University
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Mori Asami
Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences
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Ishii Kunio
Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences
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Noguchi Masahiro
Department of Chemical Engineering, Kobe University
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