Flow Regulates Vasodilator Responses to Acetylcholine in the Isolated Canine Mesenteric Arterial Bed
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概要
- 論文の詳細を見る
Raising the flow rate of the perfusate from 10 to 20 ml/min significantly suppressed vasodilator responses to acetylcholine, but not to sodium nitroprusside, in the isolated canine mesenteric arterial bed. Both acetylcholine and sodium nitroprusside augmented guanosine 3', 5'-cyclic monophosphate (cyclic GMP) levels in the effluent from the vascular bed preparation, though cyclic GMP responses to these agents were not affected by raising the flow rate. These data suggest that the suppression, via raising the flow rate, of vasodilator responses to acetylcholine is not due to impaired function of the nitric oxide (NO)-cyclic GMP pathway in the mesenteric arterial bed.
- 公益社団法人日本薬学会の論文
- 1997-05-15
著者
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Tanaka Yoshio
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Ishii Kunio
Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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NAKAYAMA Koichi
Department of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Iwate Medical
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Ishii Kunio
Dep. Of Molecular Pharmacology School Of Pharmaceutical Sciences Kitasato Univ.
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Nakayama K
Okayama Univ. Okayama Jpn
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Nakayama Koichi
Department Of Molecular And Cellular Pharmacology Faculty Of Pharmaceutical Sciences Iwate Medical U
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NAKAHARA Tsutomu
(Present adress)Department of Cardiovascular Dynamics, The National Cardiovascular Center Research I
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Nakahara Tsutomu
Dep. Of Molecular Pharmacology School Of Pharmaceutical Sciences Kitasato Univ.
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Tanaka Yoshio
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Ishii Kunio
Department Of Molecular Pharmacology Kitasato University School Of Pharmaceutical Sciences
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Nakayama Koichi
Department Of Cellular And Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Univers
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Tanaka Yoshio
Department Of Applied Chemistry Faculty Of Engineering Yokohama National University
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