Expression of Xeroderma Pigmentosum Group G (XPG) in Sporadic Breast Carcinoma
スポンサーリンク
概要
- 論文の詳細を見る
Xeroderma Pigmentosum Group G (XPG) is one of the proteins involved in nucleotide excision repair, and is related to Xeroderma pigmentosum, a rare hereditary disease characterized by hypersensitivity to ultraviolet light, high incidence of actinic carcinomas and neurological abnormalities. The aim of this study was to investigate the expression of XPG in sporadic human breast carcinoma and to determine whether its expression was predictive for response to tamoxifenbased chemotherapy and survival in the patients with breast carcinoma. We investigated the expression levels of mRNA and protein of XPG in 43 sporadic human breast carcinomas by real time PCR and immunohistochemical analysis. All the patients were primarily treated with reductive surgery and doxorubicin and tamoxifen-based regimen. XPG expression was observed in 35 of 43 cases (81.4%). The proportion of the cases with high expression level of XPG was 48.8% (21/43 cases). Interestingly, the cases showing the expression of mRNA without detectable levels of protein were observed in 5 of 43 cases (11.6%). The sequence analysis showed one mutation such as deletion at codon117 that leads to a following stop codon. Moreover, patients with high expression levels significantly had a poorer overall survival than those with low expression level (P = 0.048). These results suggest that XPG may be the useful molecular marker to choose the anticancer drugs for tamoxifen-based chemotherapy in human sporadic breast carcinoma.
著者
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SAKAMOTO Wataru
Department of Applied Chemistry, Graduate School of Engineering, Nagoya University
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Koyama Yoshihisa
Department Of Anatomy And Neuroscience Osaka University Graduate School Of Medicine
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Takebayashi Yuji
Department Of Cancer Chemotherapy Institute For Cancer Research
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OHSHIMA Takashi
Department of Agricultural Chemistry, Utsunomiya University
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Iwadate Manabu
Department Of Surgery Ii Fukushima Medical University
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Abe Noriko
Department Of Obstetrics And Gynecology Juntendo University School Of Medicine
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Nakayama Koichi
Department Of Cellular And Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Univers
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Okayama Hirokazu
Department Of Organ Regulatory Surgery Fukushima Medical University School Of Medicine
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Saito Masaru
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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Ito Jun
Department Of Anesthesiology Tohoku University Postgraduate Mdical School
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Momma Tomoyuki
Department of Organ Regulatory Surgery, Fukushima Medical University School of Medicine
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TAKENOSHITA SEIICHI
Department of Organ Regulatory Surgery
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MATSUMOTO Yoshiko
Department of Applied Biochemistry, Tokai University
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Higashimoto Masashi
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Yoshimoto Nobuhiro
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Sugeno Hidekazu
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Sassa Motoki
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Ishigame Teruhide
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Fujita Shotaro
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Gonda Kenji
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Ishii Maiko
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Urazumi Kojiro
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Sassa Motoki
Department of Organ Regulatory Surgery, Fukushima Medical University
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Sugeno Hidekazu
Department of Organ Regulatory Surgery, Fukushima Medical University
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Ishigame Teruhide
Department of Organ Regulatory Surgery, Fukushima Medical University
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Yoshimoto Nobuhiro
Department of Organ Regulatory Surgery, Fukushima Medical University
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Higashimoto Masashi
Department of Organ Regulatory Surgery, Fukushima Medical University
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Matsumoto Yoshiko
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Momma Tomoyuki
Department of Organ Regulatory Surgery, Fukushima Medical University
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Fujita Shotaro
Department of Organ Regulatory Surgery, Fukushima Medical University
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Nakayama Koichi
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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