Total Synthesis and Chemical Biology of the Sarcodictyins
スポンサーリンク
概要
- 論文の詳細を見る
The sarcodictyins A-F and eleutherobin comprise a family of marine-derived diterpenoids with potent cytotoxicities against various tumor cell lines. Investigations have revealed that several of thess compounds exert their cytotoxic effects through tubulin binding in a mechanism analogous to that of the clinical anticancer drug taxol^<TM>. The biological importance, challenging molecular architecture, and relative scarcity of these natural products have prompted several groups to undertake their total chemical synthesis. In this review, we summarize the current synthetic efforts and examine the preliminary structure-activity relationships which have emerged from early combinatorial libraries.
- 公益社団法人日本薬学会の論文
- 1999-09-15
著者
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Kim Sanghee
Department Of Mechanical Engineeringt Kaist:biomems Team Etri
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Kim Sanghee
Department Of Chemistry And The Skaggs Institute For Chemical Biology The Scripps Research Institute
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LI Tianhu
Department of Chemistry, 3 Science Drive 3, National University of Singapore
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Li T
Department Of Chemistry And The Skaggs Institute For Chemical Biology The Scripps Research Institute
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Li Tianhu
Department Of Chemistry 3 Science Drive 3 National University Of Singapore
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HOSOKAWA Seijiro
Department of Applied Chemistry, School of Science and Engineering, Waseda University
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OHSHIMA Takashi
Department of Agricultural Chemistry, Utsunomiya University
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NICOLAOU K.C.
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institut
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PFEFFERKORN Jeffrey
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institut
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XU Jinyou
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institut
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WINSSINGER Nicolas
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institut
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VOURLOUMIS Dionisios
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institut
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VAN DELFT
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institut
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Van Delft
Department Of Chemistry And The Skaggs Institute For Chemical Biology The Scripps Research Institute
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Xu J
Department Of Chemistry And The Skaggs Institute For Chemical Biology The Scripps Research Institute
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Nicolaou K
Department Of Chemistry And The Skaggs Institute For Chemical Biology The Scripps Research Institute
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Hosokawa S
Department Of Chemistry And The Skaggs Institute For Chemical Biology The Scripps Research Institute
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Hosokawa Seijiro
Department Of Applied Chemistry School Of Science And Engineering Waseda University
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Winssinger Nicolas
Department Of Chemistry And The Skaggs Institute For Chemical Biology The Scripps Research Institute
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Pfefferkorn Jeffrey
Department Of Chemistry And The Skaggs Institute For Chemical Biology The Scripps Research Institute
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Vourloumis Dionisios
Department Of Chemistry And The Skaggs Institute For Chemical Biology The Scripps Research Institute
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Ohshima Takashi
Department Of Chemistry And The Skaggs Institute For Chemical Biology The Scripps Research Institute
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