Expression of Cyclooxygenase-1, -2, Peroxisome Proliferator-activated Receptor gamma in Human Colorectal Carcinoma.

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概要

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• Purpose: The cyclooxygenases (COX) catalyze the formation of prostaglandins, affecting cell proliferation and altering the response of the immune system in malignant cells. The inducible forms of COX-1 and COX-2, have been shown to be important in carcinogenesis. Peroxisome-proliferator activated receptor gamma (PPARgamma) belongs to a family of nuclear receptors and acts as receptor for peroxisome-proliferators, steroids, retinoic acids, and polyunsaturated fatty acids. The aim of this study is to investigate the clinicopathological significance of the expressions of COX-1, COX-2 and PPARgamma genes in 90 colorectal carcinomas.Experimental Design: The expressions of COX-1, COX-2 and PPARgamma genes were examined in surgical specimens of colorectal carcinoma and corresponding normal tissues from 90 patients using modified Real Time PCR.Result: There was increase in the expression of PPARgamma in colorectal carcinomas compared to paired normal tissue (p = 0.03). Greater COX-2 expression was correlated with lymph node metastasis (p = 0.02) and venous invasion (p = 0.01).

著者

• SAKAMOTO Wataru

  Department of Applied Chemistry, Graduate School of Engineering, Nagoya University

• Koyama Yoshihisa

  Department Of Anatomy And Neuroscience Osaka University Graduate School Of Medicine

• Takebayashi Yuji

  Department Of Cancer Chemotherapy Institute For Cancer Research

• OHSHIMA Takashi

  Department of Agricultural Chemistry, Utsunomiya University

• Iwadate Manabu

  Department Of Surgery Ii Fukushima Medical University

• Abe Noriko

  Department Of Obstetrics And Gynecology Juntendo University School Of Medicine

• Saito Masaru

  Department Of Applied Chemistry Faculty Of Science And Technology Keio University

• Miyamoto Kotaro

  Department Of Organ Regulatory Surgery Fukushima Medical University School Of Medicine

• Momma Tomoyuki

  Department of Organ Regulatory Surgery, Fukushima Medical University School of Medicine

• TAKENOSHITA SEIICHI

  Department of Organ Regulatory Surgery

• SATO YU

  Department of Organ Regulatory Surgery

• Ohshima Takashi

  Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine

• Higashimoto Masashi

  Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine

• Ono Koichiro

  Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine

• Ono Tomojiro

  Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine

• Yoshimoto Nobuhiro

  Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine

• Sugeno Hidekazu

  Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine

• Sassa Motoki

  Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine

• Ishigame Teruhide

  Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine

• Fujita Shotaro

  Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine

• Shigaki Kotaro

  Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine

• Ono Koichiro

  Department of Organ Regulatory Surgery, Fukushima Medical University

• Ono Tomojiro

  Department of Organ Regulatory Surgery, Fukushima Medical University

• Sassa Motoki

  Department of Organ Regulatory Surgery, Fukushima Medical University

• Sugeno Hidekazu

  Department of Organ Regulatory Surgery, Fukushima Medical University

• Ishigame Teruhide

  Department of Organ Regulatory Surgery, Fukushima Medical University

• Yoshimoto Nobuhiro

  Department of Organ Regulatory Surgery, Fukushima Medical University

• Higashimoto Masashi

  Department of Organ Regulatory Surgery, Fukushima Medical University

• Sakamoto Wataru

  Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine

• Koyama Yoshihisa

  Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine

• Momma Tomoyuki

  Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine

• Momma Tomoyuki

  Department of Organ Regulatory Surgery, Fukushima Medical University

• Fujita Shotaro

  Department of Organ Regulatory Surgery, Fukushima Medical University

• Saito Masaru

  Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine

• Abe Noriko

  Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine

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