Expression of Cyclooxygenase-1, -2, Peroxisome Proliferator-activated Receptor gamma in Human Colorectal Carcinoma.
スポンサーリンク
概要
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Purpose: The cyclooxygenases (COX) catalyze the formation of prostaglandins, affecting cell proliferation and altering the response of the immune system in malignant cells. The inducible forms of COX-1 and COX-2, have been shown to be important in carcinogenesis. Peroxisome-proliferator activated receptor gamma (PPARgamma) belongs to a family of nuclear receptors and acts as receptor for peroxisome-proliferators, steroids, retinoic acids, and polyunsaturated fatty acids. The aim of this study is to investigate the clinicopathological significance of the expressions of COX-1, COX-2 and PPARgamma genes in 90 colorectal carcinomas.Experimental Design: The expressions of COX-1, COX-2 and PPARgamma genes were examined in surgical specimens of colorectal carcinoma and corresponding normal tissues from 90 patients using modified Real Time PCR.Result: There was increase in the expression of PPARgamma in colorectal carcinomas compared to paired normal tissue (p = 0.03). Greater COX-2 expression was correlated with lymph node metastasis (p = 0.02) and venous invasion (p = 0.01).
著者
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SAKAMOTO Wataru
Department of Applied Chemistry, Graduate School of Engineering, Nagoya University
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Koyama Yoshihisa
Department Of Anatomy And Neuroscience Osaka University Graduate School Of Medicine
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Takebayashi Yuji
Department Of Cancer Chemotherapy Institute For Cancer Research
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OHSHIMA Takashi
Department of Agricultural Chemistry, Utsunomiya University
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Iwadate Manabu
Department Of Surgery Ii Fukushima Medical University
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Abe Noriko
Department Of Obstetrics And Gynecology Juntendo University School Of Medicine
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Saito Masaru
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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Miyamoto Kotaro
Department Of Organ Regulatory Surgery Fukushima Medical University School Of Medicine
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Momma Tomoyuki
Department of Organ Regulatory Surgery, Fukushima Medical University School of Medicine
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TAKENOSHITA SEIICHI
Department of Organ Regulatory Surgery
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SATO YU
Department of Organ Regulatory Surgery
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Ohshima Takashi
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Higashimoto Masashi
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Ono Koichiro
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Ono Tomojiro
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Yoshimoto Nobuhiro
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Sugeno Hidekazu
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Sassa Motoki
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Ishigame Teruhide
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Fujita Shotaro
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Shigaki Kotaro
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Ono Koichiro
Department of Organ Regulatory Surgery, Fukushima Medical University
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Ono Tomojiro
Department of Organ Regulatory Surgery, Fukushima Medical University
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Sassa Motoki
Department of Organ Regulatory Surgery, Fukushima Medical University
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Sugeno Hidekazu
Department of Organ Regulatory Surgery, Fukushima Medical University
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Ishigame Teruhide
Department of Organ Regulatory Surgery, Fukushima Medical University
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Yoshimoto Nobuhiro
Department of Organ Regulatory Surgery, Fukushima Medical University
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Higashimoto Masashi
Department of Organ Regulatory Surgery, Fukushima Medical University
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Sakamoto Wataru
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Koyama Yoshihisa
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Momma Tomoyuki
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Momma Tomoyuki
Department of Organ Regulatory Surgery, Fukushima Medical University
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Fujita Shotaro
Department of Organ Regulatory Surgery, Fukushima Medical University
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Saito Masaru
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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Abe Noriko
Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine
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