CLINICAL EVALUATION OF DENDRITIC CELLS VACCINATION FOR ADVANCED CANCER PATIENTS AT FUKUSHIMA MEDICAL UNIVERSITY

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概要

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• Dendritic cells (DCs) are powerful antigen-presenting cells (APCs) that have attracted attention in recent years from the viewpoint of DC vaccine therapy against cancer. However, the existence of a strongly immunosuppressed state in cancer-bearing individuals inhibits DC maturation, which is one of the problems facing anti-cancer DC vaccine therapy. Isolated DCs loaded with tumor antigen ex vivo and administered as a cellular vaccine have been found to induce protective and therapeutic anti-tumor immunity in experimental animals. In clinical trials of DC vaccination for cancer patients, induction of anti-tumor immune responses and tumor regression has been observed. In this study, eighty-one advanced cancer patients unsuccessfully treated by established treatment in individual cases were selected between January 2002 and May 2007 at Fukushima Medical University. The usefulness of DC therapy was investigated by intradermal injection of peptide pulsed DCs for an overall objective response rate of 28.0%. Furthermore, direct injection of immature DCs into tumor extracted an overall objective response rate of 35.7%, and especially 40.0% for advanced pancreatic cancer by using endoscopic ultrasound-guided fine-needle injection technique as a novel approach. These results indicate that DC-based vaccination could be a promising treatment modality for various cancers, however multiple hurdles must be cleared before the development of an affordable DC-based vaccination can be used worldwide.

著者

• Shimura Tatsuo

  Department Of General Surgical Science (surgery I) Gunma University Graduate School Of Medicine

• Nakamura Izumi

  Department Of Hygiene Teikyo University School Of Medicine

• Kenjo Akira

  Department Of Biochemistry Fukushima Medical University

• Takagi Tadayuki

  Department Of Gastroenterology Aichi Cancer Center Hospital

• Ohto Hitoshi

  Department Of Cardiology And Hematology Fukushima Medical University

• Sato Yu

  Department Of Organ Regulatory Surgery Fukushima Medical University School Of Medicine

• Irisawa Atsushi

  Department Of Gastroenterology And Rheumatology Fukushima Medical University School Of Medicine

• Ogata Takashi

  Department Of Applied Chemistry And Chemical Engineering Faculty Of Engineering Kagoshima University

• Ohira Hiromasa

  Department Of Gastroenterology And Rheumatology Fukushima Medical University

• Shibata Masahiko

  Department Of Pain Medicine Osaka University Graduate School Of Medicine

• Suzuki Hiroyuki

  Department Of Animal Science Faculty Of Agriculture Hokkaido University

• TAKENOSHITA SEIICHI

  Department of Organ Regulatory Surgery

• Kanazawa Masashi

  Department of Organ Regulatory Surgery

• Kashimura Shogo

  Department of Organ Regererative Surgery

• Goto Mitsukazu

  Department of Organ Regererative Surgery

• NAKAMURA IZUMI

  Department of Organ Regulatory Surgery

• SATO YU

  Department of Organ Regulatory Surgery

• OHIRA HIROMASA

  Department of Gastroenterology and Rheumatology

• IRISAWA ATSUSHI

  Department of Gastroenterology and Rheumatology

• TAKAGI TADAYUKI

  Department of Gastroenterology and Rheumatology

• SHIBATA MASAHIKO

  Department of Tumor Host Bioscience

• OHTO HITOSHI

  Department of Blood Transfusion and Transplantation Immunology

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