CLINICAL EVALUATION OF DENDRITIC CELLS VACCINATION FOR ADVANCED CANCER PATIENTS AT FUKUSHIMA MEDICAL UNIVERSITY
スポンサーリンク
概要
- 論文の詳細を見る
Dendritic cells (DCs) are powerful antigen-presenting cells (APCs) that have attracted attention in recent years from the viewpoint of DC vaccine therapy against cancer. However, the existence of a strongly immunosuppressed state in cancer-bearing individuals inhibits DC maturation, which is one of the problems facing anti-cancer DC vaccine therapy. Isolated DCs loaded with tumor antigen ex vivo and administered as a cellular vaccine have been found to induce protective and therapeutic anti-tumor immunity in experimental animals. In clinical trials of DC vaccination for cancer patients, induction of anti-tumor immune responses and tumor regression has been observed. In this study, eighty-one advanced cancer patients unsuccessfully treated by established treatment in individual cases were selected between January 2002 and May 2007 at Fukushima Medical University. The usefulness of DC therapy was investigated by intradermal injection of peptide pulsed DCs for an overall objective response rate of 28.0%. Furthermore, direct injection of immature DCs into tumor extracted an overall objective response rate of 35.7%, and especially 40.0% for advanced pancreatic cancer by using endoscopic ultrasound-guided fine-needle injection technique as a novel approach. These results indicate that DC-based vaccination could be a promising treatment modality for various cancers, however multiple hurdles must be cleared before the development of an affordable DC-based vaccination can be used worldwide.
著者
-
Shimura Tatsuo
Department Of General Surgical Science (surgery I) Gunma University Graduate School Of Medicine
-
Nakamura Izumi
Department Of Hygiene Teikyo University School Of Medicine
-
Kenjo Akira
Department Of Biochemistry Fukushima Medical University
-
Takagi Tadayuki
Department Of Gastroenterology Aichi Cancer Center Hospital
-
Ohto Hitoshi
Department Of Cardiology And Hematology Fukushima Medical University
-
Sato Yu
Department Of Organ Regulatory Surgery Fukushima Medical University School Of Medicine
-
Irisawa Atsushi
Department Of Gastroenterology And Rheumatology Fukushima Medical University School Of Medicine
-
Ogata Takashi
Department Of Applied Chemistry And Chemical Engineering Faculty Of Engineering Kagoshima University
-
Ohira Hiromasa
Department Of Gastroenterology And Rheumatology Fukushima Medical University
-
Shibata Masahiko
Department Of Pain Medicine Osaka University Graduate School Of Medicine
-
Suzuki Hiroyuki
Department Of Animal Science Faculty Of Agriculture Hokkaido University
-
TAKENOSHITA SEIICHI
Department of Organ Regulatory Surgery
-
Kanazawa Masashi
Department of Organ Regulatory Surgery
-
Kashimura Shogo
Department of Organ Regererative Surgery
-
Goto Mitsukazu
Department of Organ Regererative Surgery
-
NAKAMURA IZUMI
Department of Organ Regulatory Surgery
-
SATO YU
Department of Organ Regulatory Surgery
-
OHIRA HIROMASA
Department of Gastroenterology and Rheumatology
-
IRISAWA ATSUSHI
Department of Gastroenterology and Rheumatology
-
TAKAGI TADAYUKI
Department of Gastroenterology and Rheumatology
-
SHIBATA MASAHIKO
Department of Tumor Host Bioscience
-
OHTO HITOSHI
Department of Blood Transfusion and Transplantation Immunology
関連論文
- High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers
- Pancreatobiliary drainage using the EUS-FNA technique : EUS-BD and EUS-PD
- EARLY DIAGNOSIS OF SMALL PANCREATIC CANCER : ROLE OF ENDOSCOPIC ULTRASONOGRAPHY
- Endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses with rapid on-site cytological evaluation by endosonographers without attendance of cytopathologists
- Symmetry Breaking in a Frustrated Heisenberg Spin System, ZnCr_2O_4 : I. Magnetic Measurements(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Hepatic Adenomatous Hyperplasia with Hyperattenuation on CT During Arterial Portography: A Case Report
- Hepatocellular Carcinoma Associated with Wilson's Disease
- Six cases of primary biliary cirrhosis complicated by psoriasis
- A case of merged idiopathic portal hypertension in course of mixed connective tissue disease
- Expression of human glucocorticoid receptor in lymphocytes of patients with autoimmune hepatitis
- High frequency of anti-ribosomal P antibody in patients with systemic lupus erythematosus-associated hepatitis
- Conversion from Total Cavopulmonary Shunt to Fontan Circulation : Improved Cyanosis with an 11-Year Interval
- Usefulness of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for undiagnosed intra-abdominal lymphadenopathy
- The efficacy of ursodeoxycholic acid and bezafibrate combination therapy for primary biliary cirrhosis : A prospective, multicenter study
- Segmental Dilatation of the Ileum Covered Almost Entirely by Gastric Mucosa : Report of a Case
- 104. Excretion of Methyl Mercury Chloride in Germfree Mice. (The Second Meeting for the Study of Toxic Effect)
- BRM cocktail treatment using PSK and OK432 significantly up-regulates the migration activity in human dendritic cells without losing effective CTL induction
- Role of Neurofibromin in Modulation of Expression of the Tyroshinase-Related Protein 2 Gene
- Differential Tissue-Specific Expression of Neurofibromin Isoform mRNAs in Rat^1
- Evidence for the Presence of Two Amino-Terminal Isoforms of Neurofibromin, a Gene Product Responsible for Neurofibromatosis Type 1
- Serum concentrations of soluble HLA-class I and CD8 forms in patients with viral hepatic disorders
- The changes of serum soluble HLA-class I and CD8 concentrations during interferon treatment of chronic hepatitis C patients
- Crossover from Magnetic to Nonmagnetic Ground State in the Kondo Alloy System Ce (Ni_Pd_x) Sn
- A Case of Hepatic Angiosarcoma Supplied by Both Hepatic Artery and Portal Vein
- Takayasu's Arteritis in a 69-year-old Woman
- Two Patients with Polymyositis or Dermatomyositis Complicated with Massive Pleural Effusion
- Magnetic Properties of New Ternary Rare Earth Compounds RPt (Pd) Sb
- HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THE DEPARTMENT OF HEMATOLOGY, FUKUSHIMA MEDICAL UNIVERSITY
- A case of hepatic inflammatory pseudotumor with primary biliary cirrhosis
- MCH-01 DEVELOPMENT OF A NOVEL METHOD FOR STRETCHING DNA FIBERS ON MICROBRIDGES FABRICATED BY SINGLE-MASK INCLINED UV LITHOGRAPHY(Micro/Nanomechatronics I,Technical Program of Oral Presentations)
- EFFECTS OF HEAVY METALS ON SUSCEPTIBILITY OF MICE TO JAPANESE ENCEPHALITIS VIRUS INFECTION : 1. EFFECTS OF CADMIUM CHLORIDE AND METHYL MERCURY CHLORIDE (The 5th Meeting for the Study of Toxic Effect)
- 211. BIOTRANSFORMATION OF METHYL MERCURY CHLORIDE IN GERM-FREE MICE (The Third Meeting for the Study of Toxic Effect)
- INCREASED METHYL MERCURY RETENTION IN MICE CONSUMED WITH JAPANESE ENCEPHALITIS VIRUS INFECTION
- Rhabdomyosarcoma Presenting as an Anterior Cervical Mass in an Adult : Report of a Case
- Malignant Rhabdoid Tumor of the Colon: Report of a Case
- Usefulness of endoscopic ultrasound to diagnose the severity of chronic pancreatitis
- Neutral 1,4-Bis(3-thiapentylxanthato)butane as Sensing Material for Samarium(III) Ion
- 胆道閉鎖症術後患児におけるMRIを用いた肝形態機能の経時的変化の検討
- Anti-Calreticulin Antibodies in Patients with Inflammatory Bowel Disease
- A case of systemic lupus erythematosus complicated by pure red cell aplasia and idiopathic portal hypertension after thymectomy
- A case of idiopathic portal hypertension associated with rheumatoid arthritis
- Lipo prostaglandin E1 reduces the production of CXC chemokines in endotoxin-induced rat liver injury
- Analysis of peripheral blood mononuclear cell stimulated with pyruvate dehydrogenase complex, T-cell receptors from patients with primary biliary cirrhosis
- High serum levels of vascular endothelial growth factor in patients with human hepatocellular carcinoma
- Antithrombin III stimulates prostaglandin I_2 production by cultured rat hepatic sinusoidal endothelial cells
- Histological diagnosis of autoimmune pancreatitis using EUS-guided trucut biopsy : a comparison study with EUS-FNA
- Evaluation of Prognoses of Patients with Gastric Cancer by the Responsiveness of Peripheral Blood Lymphocyte to OK432 in vitro
- Clinical Significance of Serum Soluble HLA Class I Antigens in Systemic Lupus Erythematosus
- INTERVENTIONAL ENDOSCOPIC ULTRASONOGRAPHY : APPLICATIONS FOR CANCER RELATED TREATMENT
- Clinicolaboratory characteristics of patients with primary biliary cirrhosis associated with CREST symptoms
- AN ELECTRONIC RADIAL SCANNING ECHOENDOSCOPE IS SUPERIOR TO A MECHANICAL RADIAL SCANNING ECHOENDOSCOPE IN ULTRASOUND IMAGE QUALITY FOR GASTROINTESTINAL TRACT AND PANCREATICOBILIARY LESIONS
- Purkinje Cell Activity in the Middle Zone of the Cerebellar Flocculus during Optokinetic and Vestibular Eye Movement in Cats
- Analysis of CD8 T-cell response by IFNγ ELISPOT and H-2L^d/pRL1a tetramer assays in pRL1a multiple antigen peptide-immunized and RL male 1-bearing BALB/c and (BALB/c×C57BL/6) F_1 mice
- Complete response of anaplastic pancreatic carcinoma to paclitaxel treatment selected by chemosensitivity testing
- Systemic lupus erythematosus, complicated with refractory skin ulcers, treated successfully with bosentan
- Clinical impact of radiotherapy for locally advanced pancreatic cancer
- Primary sclerosing cholangitis with marked eosinophilic infiltration in the liver
- Mixed Connective Tissue Disease with Severe Pulmonary Hypertension and Extensive Subcutaneous Calcification
- Effect of side-down tilt on optokinetic nystagmus and optokinetic after-nystagmus in cats
- Difference between Horizontal and Vertical Optokinetic Nystagmus in Cats at Upright Position
- PROSPECTIVE RANDOMIZED COMPARATIVE STUDY OF HEMODYNAMIC CHANGES BETWEEN ULTRATHIN TRANSNASAL AND CONVENTIONAL TRANSORAL ESOPHAGOGASTRODUODENOSCOPY IN PERCUTANEOUS ENDOSCOPIC GASTROSTOMY PLACEMENT WITH MODIFIED INTRODUCER METHOD UNDER SEDATION
- T-cell clonality of peripheral blood from patients with chronic hepatitis C before and after treatment with interferon α
- Amelanotic malignant melanoma of the esophagus : report of a patient with recurrence successfully treated with chemoendocrine therapy
- Time course of tonal frequency-response-area of primary auditory cortex neurons in alert cats
- Critical spectral regions for vowel identification
- Is ^F-fluorodeoxyglucose positron emission tomography meaningful for estimating the efficacy of corticosteroid therapy in patients with autoimmune pancreatitis?
- Saccade eye movements as a quantitative measure of frontostriatal network in children with ADHD
- A long-term remission of renal amyloidosis with nephrotic syndrome after autologous peripheral blood stem-cell transplantation
- Therapy-related myelodysplastic syndrome following cyclophosphamide pulse and/or methotrexate therapy in a patient with systemic lupus erythematosus.
- Etodolac inhibits interleukin-6 production and improves survival combined with chemotherapy in a colon 26 cachexia model
- Effect of Transarterial Immunoembolization as Preoperative Treatment for Hepatocellular Carcinoma
- Clinical features of liver dysfunction in collagen diseases
- FEASIBILITY OF INTERVENTIONAL ENDOSCOPIC ULTRASOUND USING FORWARD-VIEWING AND CURVED LINEAR-ARRAY ECHOENDOSCOPE : A LITERATURE REVIEW
- ANALYSIS OF PROGNOSTIC FACTORS IN PATIENTS WITH GASTRIC VARICES AFTER ENDOSCOPIC TREATMENT
- ENDOSCOPIC ULTRASOUND-GUIDED CHOLEDOCHODUODENOSTOMY
- Time Course of Cerebellar Flocculus Visual Complex Spike Responses
- Diagnostic approach to pancreatic tumors with the specimens of endoscopic ultrasound-guided fine needle aspiration
- Curvature pinching theorem for minimal surfaces with constant Kaehler angle in complex projective spaces
- Ectopic expression of MECA-79 as a novel prognostic indicator in gastric cancer
- Human brain activity associated with painful mechanical stimulation to muscle and bone
- ATP assay-guided chemosensitivity testing for gemcitabine with biopsy specimens obtained from unresectable pancreatic cancer using endoscopic ultrasonography-guided fine-needle aspiration
- Gene expression analysis for predicting gemcitabine resistance in human cholangiocarcinoma
- Impaired regulatory T cell reconstitution in patients with acute graft-versus-host disease and cytomegalovirus infection after allogeneic bone marrow transplantation
- Curvature pinching theorem for minimal surfaces with constant Kaehler angle in complex projective spaces, II
- CLINICAL EVALUATION OF DENDRITIC CELLS VACCINATION FOR ADVANCED CANCER PATIENTS AT FUKUSHIMA MEDICAL UNIVERSITY
- Hepatocellular Carcinoma that Relapsed 54 Months after Living Donor Liver Transplantation
- Phase I trial of preoperative intratumoral injection of immature dendritic cells and OK-432 for resectable pancreatic cancer patients
- Small bud of probable gastrointestinal stromal tumor within a laparoscopically-resected gastric schwannoma
- Pathological complete response of locally advanced gastric cancer after four courses of neoadjuvant chemotherapy with paclitaxel plus cisplatin : report of a case
- Association of the toll-like receptor 9 gene polymorphisms with behcet's disease in a Japanese population
- Utility of peppermint oil for endoscopic diagnosis of gastric tumors
- Gastric Antral Vascular Ectasia (GAVE) Associated with Systemic Sclerosis: Relapse after Endoscopic Treatment by Argon Plasma Coagulation
- Serotonin2C receptor mRNA editing in neuropathic pain model
- A CASE OF TRANSGASTRIC GALLBLADDER PUNCTURE AS A COMPLICATION DURING ENDOSCOPIC ULTRASOUND-GUIDED DRAINAGE OF A PANCREATIC PSEUDOCYST
- APPEARANCE OF RECTAL VARICES IN EXTRAHEPATIC PORTAL OBSTRUCTION AFTER TREATMENT FOR ESOPHAGO-GASTRIC VARICES : A CASE REPORT
- TWO CASES OF PANCREATIC ABSCESS ASSOCIATED WITH PENETRATION TO THE GASTROINTESTINAL TRACT DURING TREATMENT USING ENDOSCOPIC ULTRASOUND-GUIDED DRAINAGE
- A CASE OF ESOPHAGEAL SMALL CELL CARCINOMA ASSOCIATED WITH HYPERCALCEMIA CAUSING SEVERE ACUTE PANCREATITIS
- A CASE OF RAPIDLY EXPANDING AND INCREASING FOCAL NODULAR HYPERPLASIA
- USEFULNESS OF ENDOSCOPIC ULTRASONOGRAPHIC ANALYSIS OF VARICEAL HEMODYNAMICS FOR THE TREATMENT OF ESOPHAGEAL VARICES
- CASE OF AN ELDERLY MAN WITH ASSOCIATED HENOCH-SCHÖNLEIN PURPURA DURING TREATMENT OF ACUTE PANCREATITIS