BRM cocktail treatment using PSK and OK432 significantly up-regulates the migration activity in human dendritic cells without losing effective CTL induction

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概要

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• One of the major factors for successful DCs immunotherapy is thought to be the maintenance of the migratory activity of matured DCs. We evaluated the effectiveness of PSK on OK432-activated DCs, in terms of maturation, migration and induction of CTLs. When DCs were treated with both OK432 and PSK, migration ability of the DCs were significantly high as compared to OK432 alone preserving the beneficial effect of OK432 treatment. BRM cocktail treatment with OK432 and PSK induced high level of migration activity in activated DCs, suggesting a potential protocol for more effective DCs immunotherapy for cancer.

著者

• SUZUKI Hiroyuki

  Department of Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine

• Hoshino Mika

  Department of Surgery 1, Fukushima Medical University

• Kashimura Seigo

  Department of Surgery 1, Fukushima Medical University

• Kanzaki Norio

  Department of Surgery 1, Fukushima Medical University

• Yaginuma Hiroshi

  Department of Surgery 1, Fukushima Medical University

• Hasegawa Takeo

  Department of Surgery 1, Fukushima Medical University

• Yonechi Atsushi

  Department of Surgery 1, Fukushima Medical University

• Ohsugi Jun

  Department of Surgery 1, Fukushima Medical University

• Higuchi Mitsunori

  Department of Surgery 1, Fukushima Medical University

• Shio Yutaka

  Department of Surgery 1, Fukushima Medical University

• Ise Kazuya

  Department of Surgery 1, Fukushima Medical University

• Gotoh Mitsukazu

  Department of Surgery 1, Fukushima Medical University

• Hasegawa Takeo

  Department Of Cardiothoracic Surgery Sapporo Medical University School Of Medicine

• Gotoh Mitsukazu

  Department Of Organ Regenerative Surgery Fukushima Medical University

• Hoshino Mika

  Department Of Regenerative Surgery Fukushima Medical University

• Suzuki Hiroyuki

  Department Of Animal Science Faculty Of Agriculture Hokkaido University

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