ORNITHINE DECARBOXYLASE ACTIVITY AS A PROGNOSTIC MARKER FOR COLORECTAL CANCER
スポンサーリンク
概要
- 論文の詳細を見る
Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of polyamines, which are essential for cell proliferation. ODC activity was measured in 47 colorectal cancer patients, 5 patients with adenoma of colorectum and 4 healthy volunteers. Mean ODC activities of cancer tissue, non-cancerous mucosa from cancer-bearing colorectum, adenoma tissue, and normal mucosa from healthy volunteers were 435±392, 154±173, 295±202, 103±60 pmol CO2/h/mg protein, respectively. ODC activity of cancer tissue or adenoma tissue was significantly higher than that of the others. Among colorectal cancer patients, ODC activity in cancer tissue was correlated with T factors, lymph node metastasis and stages. Patients with tumors that had high ODC activity (≥ 350 pmol CO2/h/mg protein) showed a poor 10-year survival rate. These results suggest that ODC activity may be a useful marker for patients' prognosis after surgery.
- 福島医学会の論文
著者
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Kashimura Seigo
Department of Surgery 1, Fukushima Medical University
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Hoshino Yutaka
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Teranishi Yasushi
Department Of Surgery Southern Tohoku General Hospital
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Terashima Masanori
Department Of Surgery Fukushima Medical University
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Gotoh Mitsukazu
Department Of Organ Regenerative Surgery Fukushima Medical University
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KASHIMURA SEIGO
Department of Surgery I, Fukushima Medical University School of Medicine
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TERASHIMA SHINYA
Department of Surgery, Fujita General Hospital
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KOGURE MICHIHIKO
Department of Surgery I, Fukushima Medical University School of Medicine
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SAITOH TAKUROH
Department of Surgery I, Fukushima Medical University School of Medicine
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OSUKA FUMIHIKO
Department of Surgery I, Fukushima Medical University School of Medicine
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SAZE ZENICHIROH
Department of Surgery I, Fukushima Medical University School of Medicine
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TERASHIMA MASANORI
Department of Surgery I, Fukushima Medical University School of Medicine
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HOSHINO YUTAKA
Department of Surgery I, Fukushima Medical University School of Medicine
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