Evaluation of Prognoses of Patients with Gastric Cancer by the Responsiveness of Peripheral Blood Lymphocyte to OK432 in vitro

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概要

• 論文の詳細を見る

• The response of peripheral blood lymphocytes to the streptococcal preparation OK432 was examined in vitro in 193 gastric cancer patients. When the patients were divided by stimulation index (SI) into two groups, SI≧20 and SI<20, the response rate of SI≧20 group of stage IV was 37.5%, and higher than those of the other stages (p<0.05). In the relationship between SI and the survival period in stage III, the SI≧20 group showed longer survival than the SI<20 group (p<0.05). There was no statistically significant difference in survival between SI≧20 and SI<20 in stage IV, but no member of the SI<20 group survived more than 2 years, whereas the five-year survival of the SI≧20 group was 38.9%. In the overall survival of stage III and IV, the SI≧20 group showed longer survival than the SI<20 group (p=0.001). The lymphoproliferative responses to OK432 decreased in very advanced gastric cancer patients and this might lead to poor prognosis.

• 東海大学の論文

著者

• Ogoshi Kyoji

  Department of Gastroenterological Surgery, Tokai University

• TAKENOSHITA Seiichi

  Department of Surgery II, Fukushima Medical School

• MITOMI Toshio

  Department of Surgery, School of Medicine, Tokai University

• SHIMURA TATSUO

  Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine

• Shimura Tatsuo

  Department Of Surgery Gumma University School Of Medicine

• Shimura Tatsuo

  東海大学 移植免疫

• Shimura Tatsuo

  Department Of General Surgical Science (surgery I) Gunma University Graduate School Of Medicine

• Ogoshi Kyoji

  Department Of Surgery Tokai University School Of Medicine

• Hagihara Masao

  Department Of Hematology And Oncology Tokai University School Of Medicine

• TAKEBE Kentaro

  Department of Surgery, Gumma University School of Medicine

• TSUJI Kimiyoshi

  Department of Transplantation Immunology, Tokai University School of Medicine

• Tsuchida F

  Tokai Univ. School Of Medicine Kanagawa Jpn

• Takenoshita S

  Department Of Second Surgery Fukushima Prefecture College School Of Medicine

• NAGAMACHI Yukio

  Department of Surgery, Gunma University School of Medicine

• Tsuji K

  Department Of Transplantation Immunology Tokai University School Of Medicine

• Tsuji Kimiyoshi

  Department Of Transplantation Ii School Of Medicine Tokai University

• Nagamachi Y

  Gunma Univ. Maebashi Jpn

• Nagamachi Yukio

  Department Of Surgery Gunma University School Of Medicine

• Tsuchida Fumiko

  Transplantation Immunology Center Tokai University School Of Medicine

• Takenoshita Seiichi

  Department Of Second Surgery Fukushima Prefecture College School Of Medicine

• Takebe Kentaro

  Department Of Surgery Gumma University School Of Medicine

• Mitomi Toshio

  Department Of 2nd Surgery School Of Medicine Tokai University

• Takenoshita Seiichi

  Department Of Organ Regulatory Surgery Fukushima Medical University School Of Medicine

• TAKENOSHITA SEIICHI

  Department of Organ Regulatory Surgery

• TSUJI KIMIYOSHI

  Department of Radiology, School of Medicine, Keio University

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