Effect of Cholecystokinin-A Receptor Antagonist on Rat Pancreas after Partial Pancreatectomy(Prof. K Watanabe Memorial Article)
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概要
- 論文の詳細を見る
Our previous study indicated that the acinar cells regenerated actively in the rat pancreatic remnant after partial (90%) pancreatectomy. On that occasion, a twofold higher mitotic activity was observed in the cells of paraduodenal than those of the medial and stump regions (regional difference). Since cholecystokinin (CCK) has been known to have various physiological functions in the digestive system, especially in the pancreas, through the CCK-A receptor, we determined the effect of a CCK-A receptor competitive antagonist (CCK-RA) (SR27897B) on pancreatic regeneration after pancreatectomy. A group of Wistar rats was administered 1 mg/kg CCK-RA twice daily for 5 days. On the 2nd day of administration, partial pancreatectomy was performed. Proliferation activity of both exocrine and endocrine cells was found to be enhanced uniformly 5 days after the pancreatectomy, and the effect was inhibited by CCK-RA. Plasma CCK level was increased by 90% pancreatectomy and decreased by CCK-RA. CCK was hypothesized to be an important factor of pancreatic exocrine and endocrine regeneration. Administration with CCK-RA suppressed mitotic activity uniformly in the three regions of paraduodenal, medial and stump. From the evidence, it was presumed that regional difference in regeneration was produced not by paracrine factor from the duodenum but by some other unknown mechanism including anatomical difference in vascular and autonomic nervous system.
- 日本組織細胞化学会の論文
著者
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TAKAHASHI Tsuyoshi
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo
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林 京子
北里大学医学部外科
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林 京子
北里大学外科
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林 京子
Departments Of Surgery Kitasato University School Of Medicine
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YAMASHINA Shohei
Department of Anatomy, Kitasato University School of Medicine
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Hayashi Keiko
Department of Medical Technology Nagoya University School of Health Sciences
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KAKITA AKIRA
Department of Surgery, Kitasato University
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Takenoshita S
Department Of Second Surgery Fukushima Prefecture College School Of Medicine
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Handa Kimiya
Departments of Surgery, Kitasato University School of Medicine
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Suzuki Tetsutaro
Departments of Surgery, Kitasato University School of Medicine
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Handa Kimiya
Departments Of Surgery Kitasato University School Of Medicine
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林 京子
富山医科薬科大学医学部
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Suzuki Tetsutaro
Departments Of Surgery Kitasato University School Of Medicine
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Yamashina Shohei
Departments Of Anatomy Kitasato University School Of Medicine
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Yamashina Shohei
Dept. Pharmaceutical Science Tohoku University
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Yamashina Shohei
Department Of Anatomy And Cell Biology Kitasato University School Of Medicine
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Takahashi Tsuyoshi
Department Of Hematology And Oncology Graduate School Of Medicine University Of Tokyo
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Kakita A
Departments Of Surgery Kitasato University School Of Medicine
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Kakita Akira
Department Of Gastroenterology Kitasato University
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Suzuki T
Departments Of Surgery Kitasato University School Of Medicine
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Handa Kimiya
Department Of Surgery Kitasato University School Of Allied Health Sciences
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Takahashi Tsuyoshi
Fujitsu Limited
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Hayashi Keiko
Department Of Dermatology Faculty Of Medicine University Of Tokyo
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Yamashina Shohei
Departmant Of Anatomy And Cell Biology Tokyo Medical And Dental University
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Suzuki Toshihide
Compound Semiconductor Devices Lab Fujitsu Laboratories Ltd.
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Suzuki Takeshi
Laboratory Of Microbial Biochemistry Institute For Chemical Research Kyoto University
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Hayashi Keiko
Department Of Biological Science And Technology Faculty Of Engineering The University Of Tokushima
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Takahashi Tsuyoshi
Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicine
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