FINE STRUCTURAL CHANGES IN THE HEPATIC MICROBODIES OF RATS TREATED WITH HYPOLIPIDEMIC AGENTS, GEMFIBROZIL AND CLOFIBRATE
スポンサーリンク
概要
- 論文の詳細を見る
Fine structural changes in the hepatic microbodies of male adult rats treated with a newly developed hypolipidemic agent, gemfibrozil, were compared with results of clofibrate treatment. Both drugs caused a hepatic microbody proliferation and elevation of the catalase activity in the liver, in spite of their different chemical structures. A significant difference was observed, however, in the ultrastructure of the microbodies of the two drugs. An appearance of tubular substructure was evident in the matrix of hepatic microbodies dueto the effect of gemfibrozil, in contrast to clofibrate which caused an occurrence of fibrous substructures.
- 日本組織細胞化学会の論文
著者
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Mizuhira Vinci
Department Of Anatomy And Cell Biology Medical Research Institute Tokyo Medical And Dental Universit
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YAMASHINA Shohei
Department of Anatomy, Kitasato University School of Medicine
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FUKUDA KUNIAKI
Central Research Laboratories, Sankyo Co., Ltd.
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SHINDO HIDEYO
Central Research Laboratories, Sankyo Co., Ltd.
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Shindo Hideyo
Central Research Laboratories Sankyo Co. Ltd.
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Fukuda Kuniaki
Central Research Laboratories Sankyo Co. Ltd.
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Yamashina Shohei
Department Of Anatomy And Cell Biology Medical Research Institute Tokyo Medical And Dental Universit
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Yamashina Shohei
Departmant Of Anatomy And Cell Biology Tokyo Medical And Dental University
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Mizuhira Vinci
Department Of Anatomy & Cell Biology Tokyo Medical & Dental University
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