AUTORADIOGRAPHIC STUDIES ON DISTRIBUTION OF L-3, 4-DIHYDROXYPHENYLALANINE (L-DOPA)-<SUP>14</SUP>C AND L-5-HYDROXYTRYPTOPHAN (L-5-HTP)-<SUP>14</SUP>C IN THE CAT BRAIN
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概要
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The distribution and metabolism of L-DOPA-<SUP>14</SUP>C and L-5-HTP-<SUP>14</SUP>C in the cat brain were examined by means of autoradiography and chromatography. The results revealed that an appreciable amount of radioactivity in the gray matter, but not the white, and that the localization profiles of radioactivity of L-DOPA and L-5-HTP significantly differed. After L-DOPA-<SUP>14</SUP>C administration, a high accumulation was found in the caudate nucleus, putamen and pallidum. With L-5-HTP-<SUP>14</SUP>C administration, high radioactivity was observed in the hypothalamus, raphe nucleus, substantia nigra, inferior olivalis and caudate nucleus. An analysis of the main metabolites of both amino acids in various regions of the brain was also made. When L-DOPA was given, a high concentration of dopamine was detected in the caudate nucleus, followed by the hypothalamus. In the case of L-5-HTP, a high concentration of serotonin was detected in the hypothalamus and the medulla oblongata. These results suggest that amines derived from exogenously administered L-DOPA and L-5-HTP accumulate in the brain regions known as the corresponding amine rich regions, under physiological conditions.
- 社団法人 日本薬理学会の論文
著者
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SHINDO HIDEYO
Central Research Laboratories, Sankyo Co., Ltd.
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MIYAKOSHI NOBUHIRO
Central Research Laboratories, Sankyo Co., Ltd.
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Shindo Hideyo
Central Research Laboratories Sankyo Co. Ltd.
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TANAKA Minoru
Central Research Laboratories, Sankyo Co., Ltd.
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Miyakoshi Nobuhiro
Central Research Laboratories Sankyo Co. Ltd.
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Tanaka Minoru
Central Research Laboratories Sankyo Co. Ltd.
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