Biphasic Accumulation of Leukocytes in Rat Cardiac Infarct Tissue Caused by Leukotriene B<SUB>4</SUB> and Complement
スポンサーリンク
概要
- 論文の詳細を見る
An initial increase (3-12 hr) in the polymorphonuclear leukocytes (PMN) counts after ligation of the rat left main coronary artery was reduced by 49.4% (at 12 hr) by a 5-lipoxygenase inhibitor, AA-861 (80 mg/kg, p.o., 1 hr before ligation). Depletion of the complement components induced by cobra venoma factor (CVF) (i.v.), given one day before, resulted in significant reduction in the PMN accumulation after 12 hr (by 63.6% at 24 hr). The combined treatment (CVF+AA-861) suppressed the PMN accumulation by 69.7% (24 hr). The infarct size at 48 hr was also reduced by approximately 36% by either AA-861, CVF or combined treatments.
著者
-
YAMASHINA Shohei
Department of Anatomy, Kitasato University School of Medicine
-
Katori Makoto
Department Of Pharmacology Kitasato University School Of Medicine
-
Ueno Akinori
Department Of Pharmacology School Of Pharmaceutical Sciences Kitasato University
-
Yamashina Shohei
Departmant Of Anatomy And Cell Biology Tokyo Medical And Dental University
-
KANAYAMA Toshiji
Pharmaceuticals Laboratory, Research Center, Mitsubishi Kasei Co.
-
SASAKI Kouji
Department of Pharmacology, Kitasato University School of Medicine
-
TAKAGI Miwako
Department of Pharmacology, Kitasato University School of Medicine
関連論文
- Effects of Liver-Supplemented Food on the Development of Embryos in Mice
- An ATP-sensitive potassium channel blocker suppresses sodium-induced hypertension through increased secretion of urinary kallikrein
- Intercalated duct cells in the rat parotid gland may behave as tissue stem cells
- PJ-798 Comparison between Long-acting and Short-acting Loop Diuretics in Chronic Heart Failure : Evaluation by I123MIBG(Heart failure, clinical-18, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- FINE STRUCTURAL CHANGES IN THE HEPATIC MICROBODIES OF RATS TREATED WITH HYPOLIPIDEMIC AGENTS, GEMFIBROZIL AND CLOFIBRATE
- Transient Prevention of Ethanol-Induced Gastric Lesion by Capsaicin Due to Release of Endogenous Calcitonin Gene-Related Peptide in Rats
- Effect of Cholecystokinin-A Receptor Antagonist on Rat Pancreas after Partial Pancreatectomy(Prof. K Watanabe Memorial Article)
- Differentiation and proliferation of endocrine cells in the regenerating rat pancreas after 90% pancreatectomy
- Regional Differences in the Cellular Proliferation Activity of the Regenerating Rat Pancreas after Partial Pancreatectomy
- Protein Gene Product 9.5 is an useful marker for differentiation of pancreatic endocrine cells
- Prediction of cardiac events in patients with dilated cardiomyopathy using ^I-BMIPP and ^Tl myocardial scintigraphy
- Significance of Delayed Image with Rest Tc-99m-sestamibi Myocardial SPECT in Patients with Acute Myocardial Infarction -as Compared with I-123-BMIPP(Nuclear Cardiology 3 (I), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Coherent-Anomaly Method in Critical Phenomena.III.Mean-Field Transfer-Matrix Method in the 2D Ising Model
- Coherent Anomaly Method in Critical Phenomena.I.
- Expression of DNA Methyltransferase (Dnmt1) in Testicular Germ Cells during Development of Mouse Embryo
- PJ-260 Regional Washout Rate of Tc-99m-sestamibi in Patients with Acute Myocardial Infarction after Successful Reperfusion(Nuclear cardiology-6 (I) PJ44,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation S
- PJ-353 Benefits of distal protection for myocardial salvage in AMI as observed by myocardial SPECT(Nuclear Cardiology 11 (I) : PJ59)(Poster Session (Japanese))
- PE-042 Benefits of thrombectomy for myocardial salvage in AMI as observed by myocardial SPECT(Nuclear Cardiology 5 (I) : PE7)(Poster Session (English))
- The expression of pancreatic endocrine markers in centroacinar cells of the normal and regenerating rat pancreas : their possible transformation to endocrine cells
- P3-19 3-D relation of endocrine cells with capillary in the developing regenerating rat pancreatic islets
- Adenylate Cyclase/Protein Kinase A Signaling Pathway Enhances Angiogenesis Through Induction of Vascular Endothelial Growth Factor In Vivo
- Salivary gland morphogenesis and basement membranes
- Distributional changes of Golgi-resident proteins and dynamics of Golgi membranes in rat parotid acinar cell
- Roles of calcitonin gene-related peptide and prostaglandin I_2 in prevention of ethanol-induced gastric mucosal microcirculatory disturbances by mild irritant in rats
- Expression of PGP9.5 in Ductal Cells of the Rat Pancreas during Development and Regeneration : Can It Be a Marker for Pancreatic Progenitor Cells?
- Cyclooxygenase-2 Inhibitors Attenuate Increased Blood Pressure in Renovascular Hypertensive Models, but Not in Deoxycorticosterone-Salt Hypertension
- Three-dimensional Dynamics of the Golgi Apparatus of Parotid Acinar Cells as Analyzed by Computer Graphics of Cytochemically-marked Serial Sections (Enzyme Cytochemistry : Recent Advances and Applications)
- Substructures of the acinar basement membrane of rat submandibular gland as shown by alcian blue staining and cryo-fixation followed by freeze-substitution
- Intracellular Ca^ Increase in Neuro-2A Cells and Rat Astrocytes Following Stimulation of Bradykinin B_2 Receptor
- Mouse Paw Edema Induced by a Novel Bradykinin Agonist and Its Inhibition by B2-Antagonists
- The Mediators Involved in Endotoxin-Induced Vascular Permeability Increase in the Rat Skin and Their Interactions
- Failure of the Oxytocin-Induced Increase in Secretion of Urinary Kallikrein in Young Spontaneously Hypertensive Rats
- Increase in Vascular Sensitivity to Angiotensin II and Norepinephrine after Four - Day Infusion of 0.3M Sodium Chloride in Conscious Kininogen - Deficient Brown Norway Katholiek Rats
- Oxytocin-Induced Natriuresis Mediated by the Renal Kallikrein-Kinin System in Anesthetized Male Rats
- A Novel Model of Pain Sensation Using Superfused Gastrosplenic Omentum Preparation of Anesthetized Rats
- Maifolded Cytochrome P-450(MI) Localized in Unusual Membrane Structures of the Eendoplasmic Reticulum in Cultured Animal Cells
- DEVELOPMENTAL CORRELATION OF THE HEART CONDUCTION SYSTEM WITH PASSAGE STRUCTURE; A COMPARATIVE STUDY ON NORMAL AND MALFORMED HEARTS
- IIB-22 Proliferation Dynamics of Parotid Cells after Repeated Injection of Isoproterenol(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Wortmannin and Li^+ Specifically Inhibit Clathrin-Independent Endocytic Internalization of Bulk Fluid
- A Potential Role of Bradykinin in Angiogenesis and Growth of S-180 Mouse Tumors
- Significant Roles of Inducible Cyclooxygenase (COX)-2 in Angiongenesis in Rat Sponge Implants
- Induction of Cyclooxygenase Type - 2(COX - 2) in Rat Endometrium at the Peak of Serum Estradiol during the Estrus Cycle
- The Stack of the Golgi Apparatus
- Study of Coherent Anomalies and Critical Exponents Based on High-Level Cluster-Variation Approximations
- RELIABLE EVIDENCE OF INVOLVEMENT OF THE KININ SYSTEM IN MOUSE MALARIA
- EVALUATION OF MICROWAVE IRRADIATION IN IMMUNOHISTOCHEMICAL REACTIONS (Microwave Fixation in Histochemistry)
- Usefullness of semi-thin cryosections for the immunohistochemical study : Counter staining with toluidin blue.
- The Use of Cerium Ions for the Demonstration of Phosphatase Activities.
- Three-dimensional Dynamics of the Golgi Apparatus in Mitotic Parotid Acinar Cells : Computer-aided Reconstruction from Cytochemically-marked Ultrathin Serial Sections
- Direct observation of microcirculation of the basal region of rat gastric mucosa
- Correlation Inequalities and Lower Bounds for the Critical Value λ_c of Contact Processes
- Applications of the CAM Based on a New Decoupling Procedure of Correlation Functions in the One-Dimensional Contact Process
- Effects of Colchicine on the Formation of Secretory Granules in the Salivary Acinar Cells.
- Electron Microscopic Studies on the Transport Mechanism of Electrolytes and Its Concerning Enzymatic Localization (Electron Microscopic Histo- and Cytochemistry,Recent Progress in Phosphatase Cytochemistry)
- Application od Atomic Force Microscopy to Ultrastructural and Histochemical Studies of Fixed and Embedded Cells
- ACCELERATION OF ENDOGENOUS PGI2 GENERATION FROM ISOLATED RAT AORTAE BY MK-447
- DUAL EFFECTS OF A BASIC ANTI-INFLAMMATORY AGENT, 2-AMINOMETHYL-4-t-BUTYL-6-IODOPHENOL HYDROCHLORIDE (MK-447), ON BIOSYNTHESIS OF PROSTAGLANDIN ENDOPEROXIDES
- A Second-Order Phase Transition as a Limit of the First-Order Phase Transitions-Coherent Anomalies and Critical Phenomena in the Potts Models-
- Roles of Arachidonate Metabolites in Thrombus Formation and Leukocyte Migration : Analyses At Microcirculatory Level
- Upper Bounds for Order Parameters of a Class of Attractive Nearest-Particle Systems with Finite Ranges
- Applications of the Harris-FKG Inequality to Upper Bounds for Order Parameters in the Contact Processes
- Three-Point Markov Extension and an Improved Upper Bound for Survival Probability of the One-Dimensional Contact Process
- Roles for the Kallikrein-Kinin System in Inflammatory Exudation and Pain : Lessons From Studies on Kininogen-Deficient Rats
- Extreme value distributions of noncolliding diffusion processes (Spectra of Random Operators and Related Topics)
- Significant role of laminin-1 in branching morphogenesis of mouse salivary epithelium cultured in basement membrane matrix
- Coherent Anomaly Method in Critical Phenomena.II.Applications to the Two-and Three-Dimensional Ising Models
- Coherent-Anomaly Method in Critical Phenomena.V. Estimation of the Dynamical Critical Exponent Δ of the Two-Dimensional Kinetic Ising Model
- Statistical Properties of Trajectories of Friendly Walkers on Spatio-Temporal Plane : General Physics
- New Method to Study Critical Phenomena-Mean-Field Finite-Size Scaling Theory
- Scaling Laws of the Nonlinear Part of Magnetization in the SK Model of Spin Glasses : Condensed Matter and Statistical Physics
- Structural and Statistical Properties of Competing Directed Percolation
- On the CAM Canonicality of the Cluster-Variation Approximations
- The Number of Directed Compact Site Animals and Extrapolation Formula of Directed Percolation Probability
- Study of Coherent Anomalies and Critical Exponents Based on the Cluster-Variation Method
- n-State Exclusive diffusion Models for Avalanche Processes Showing Self-Organized Criticality
- Low-Density Series Expansion for the Domany-Kinzel Model : General Physics
- Determination of the survival rate in patients with congestive heart failure stratified by ^I-MIBG imaging : a meta-analysis from the studies performed in Japan
- Analysis of Canopy-Gap Structures of Forests by Ising-Gibbs States-Equilibrium and Scaling Property of Real Forests-
- Exclusive Diffusion Model Showing Self-Organized Criticality
- Developmental delay and unstable state of the testes in the rdw rat with congenital hypothyroidism
- Development of the Golgi Apparatus in the Differentiating Parotid Acinar Cells (II)
- HISTOCHEMICAL DETECTION TECHNIQUE OF GLUCOSE OXIDASE
- Localization of sorbitol dehydrogenase in the mouse oviduct
- Chiral Potts Models,Friendly Walkers and Directed Percoltion Problem
- SEM observation of the insect prepared by microwave irradiation
- Disorganization of actin bundles of ectoplasmic Specialization
- Dissociation of Rat Submandibular Gland and Localization of Peroxidase Activity
- Biphasic Accumulation of Leukocytes in Rat Cardiac Infarct Tissue Caused by Leukotriene B4 and Complement
- Pivotal Role of Renal Kallikrein-Kinin System in the Development of Hypertension and Approaches to New Drugs Based on This Relationship
- Changing Anatomy Education and Introduction of Self Assessment of Teacher Performance in Japan
- Stadies on the differentiation of parotid acinar cells as revealed by histochemical localization of 5'-nucleotidase
- Fractal Structure of Isothermal Lines and Loops on the Cosmic Microwave Background
- A Missing Link Between a High Salt Intake and Blood Pressure Increase
- Fermi Partition Functions of Friendly Walkers and Pair Connectedness of Directed Percolation : General Physics
- P2-17 The Golgi apparatus of rat parotid acinar cells is consisted of the basic and functional elements
- Sodium Accumulation Induces Hypertension in Kininogen Deficient Brown Norway Katholiek Rats
- A Stable Metabolite, Arg-Pro-Pro-Gly-Phe, of Bradykinin in the Degradation Pathway in Human Plasma.
- Diuretic and Natriuretic Effect of Ebelactone B in Anesthetized Rats by Inhibition of a Urinary Carboxypeptidase Y-Like Kininase.
- Enhancement of Endogenous Prostaglandin I2 (Prostacyclin) Generation In Vivo by a Phenolic Anti-Inflammatory Agent in the Rabbit.
- Decreased activity of prostaglandin endoperoxide synthetase in prostaglandin I2 (prostacyclin). Biosynthesis from arachidonic acid in isolated rat aortae.