Enhancement of Endogenous Prostaglandin I2 (Prostacyclin) Generation In Vivo by a Phenolic Anti-Inflammatory Agent in the Rabbit.
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概要
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Angiotensin II (i.v.) increased the plasma level of 6-keto-PGF<SUB>1α</SUB> from 241 ± 60 pg/ml (n = 8) to 612 ± 108 pg/ml (n = 8) in anesthetized rabbits, which was further significantly increased by pretreatment with a phenolic anti-inflammatory agent, MK-447, to 1007 ± 218 pg/ml (n = 8). MK-447 alone did not affect the level. The level of thromboxane B<SUB>2</SUB> was not affected by these treatments. These results suggest that MK-447 may selectively enhance the PGI<SUB>2</SUB> level by acting as a tryptophan-like cofactor of PG endoperoxide synthase.
- 公益社団法人 日本薬理学会の論文
著者
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Katori Makoto
Department Of Pharmacology Kitasato University School Of Medicine
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Harada Yoshiteru
Department Of Pharmacology Kitasato University School Of Medicine
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Kawamura Michiko
Department Of Mathematics Faculty Of Education Gifu University
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