Transient Prevention of Ethanol-Induced Gastric Lesion by Capsaicin Due to Release of Endogenous Calcitonin Gene-Related Peptide in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Pre-exposure of the rat gastric mucosa to capsaicin reduced the mucosal lesion by 50% ethanol to 1/4. Treatment with an antagonist of calcitonin gene-related peptide (CGRP), CGRP (8 - 37), nullified the effect of capsaicin. During constant perfusion of the gastric lumen with physiological saline + pepstatin, the CGRP level was not increased by 50% ethanol, but it showed a peak (802.5 ± 145.7 pg/2 min) after 1.6 mM capsaicin. Four minutes after capsaicin, the CGRP level was kept at a high level and the gastric lesion was markedly reduced by re-exposure of the mucosa to 50% ethanol. At 20 - 30 min after capsaicin, the CGRP levels returned to the resting level and the reddened area by 50% ethanol was not reduced. It was concluded that capsaicin transiently prevented the mucosal lesion through CGRP release.
- 社団法人 日本薬理学会の論文
- 2001-07-01
著者
-
OHNO Takashi
Department of Psychiatry, Tohoku University Graduate School of Medicine
-
Majima Masataka
Department of Pharmacology, Kitasato University of Medicine
-
Hayashi Hiromi
Department Of Pharmacology Kitasato University School Of Medicine
-
NISHIYAMA Kazuo
Department of Pharmacology, Kitasato University School of Medicine
-
BOKU Katsuharu
Department of Pharmacology, Kitasato University School of Medicine
-
KATORI Makoto
Department of Pharmacology, Kitasato University School of Medicine
-
Katori M
Department Of Pharmacology Kitasato University School Of Medicine
-
Katori Makoto
Dep. Of Pharmacology Kitasato Univ. School Of Medicine Jpn
-
Katori Makoto
Department Of Pharmacology Kitasato University School Of Medicine
-
Boku Katsuharu
Department Of Pharmacology Kitasato University School Of Medicine
-
Matsubara Madoka
Department Of Pharmacology Kitasato University School Of Medicine
-
Majima Masataka
Department Of Orthopedic Surgery Yokkaichi Municipal Hospital
-
Majima Masataka
Departmento Of Pharmacology Kitasato University School Of Medicine
-
Majima M
Department Of Pharmacology Kitasato University School Of Medicine
-
Okanoue Takeshi
Departments Of Internal Medicine And Pharmacology Kitasato University School Of Medicine
-
Nishiyama Kazuo
Department Of Pharmacology Kitasato University School Of Medicine
-
Nishiyama Kazuo
Department Of Biological Resource Sciences Miyazaki University
-
Ohno Takashi
Department Of Agrobioscience Graduate School Of Agriculture Kobe University
-
Hayashi Hiromi
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan
-
Hayashi Hiromi
Department of Cardiology, Surugadai Nihon University Hospital
関連論文
- The Role of Cognitive-Motor Function in Precipitation and Inhibition of Epileptic Seizures
- Bilateral tubal pregnancies after the termination of intrauterine pregnancy following gamete intrafallopian transfer
- An ATP-sensitive potassium channel blocker suppresses sodium-induced hypertension through increased secretion of urinary kallikrein
- La-NQR Probe of Strong-Coupling s-Wave Superconductivity in LaRu_3Si_2(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- La-NQR Probe of Strong-Coupling s-Wave Superconductivity in LaRu_3Si_2
- Magnetic Susceptibility Study of LaRu_3Si_2
- The effects of orange juice and lemon juice on the pharmacokinetics of itraconazole and hydroxyitraconazole in healthy subjects
- NMR Study on the Chemical Bonding and the Ionic Conductivity in Noble Metal Halides
- 2P288 生合成的にSr置換された好熱性紅色硫黄細菌Thermochromatium tepidumにおける色素蛋白質複合体の特性評価(光生物-光合成,第48回日本生物物理学会年会)
- NMR Study on Defect Structure in β-LiGa(Condensed matter: structure and mechanical and thermal properties)
- NMR Study on Li^+ Ionic Motion in Li_xV_2O_5 (0.4≦x≦1.4)(Condensed matter: structure and mechanical and thermal properties)
- Transient Prevention of Ethanol-Induced Gastric Lesion by Capsaicin Due to Release of Endogenous Calcitonin Gene-Related Peptide in Rats
- Role of endogenous substance P in ethanol-induced mucosal damage in the rat stomach
- ^La NQR Relaxation in a Superconductor La_3Ir_2Ge_2(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Population Pharmacokinetic-Pharmacodynamic Modeling of TF-505 Using Extension of Indirect Response Model by Incorporating a Circadian Rhythm in Healthy Volunteers(Biopharmacy)
- Novel Screening Method for Potential Skin-Whitening Compounds by a Luciferase Reporter Assay
- Role of endogenous thromboxane in hepatic microcirculatory dysfunction during endotoxemia in mice
- Structure-Activity Relationship of Immunoregulatory Factors in Foodstuffs
- Soy-derived isoflavones inhibit the growth of adult T-cell leukemia cells in vitro and in vivo
- ^V NMR Study of A15 Superconductor V_3Si
- Temperature Dependence of the Nuclear Quadrupole Relaxation Rate in Silver and Sodium Halide Crystals
- Nuclear Quadrupole Relaxation in Silver and Sodium Halide Crystals
- Nuclear Magnetic Relaxation and Ionic Conductivity in LiNaSO_4
- NMR and Specific Heat Investigations in a Strong Electron-Phonon Coupling Superconductor HfV_2
- Electrical Impedance and Ultrasonic Measurements of Ag_3SI
- Ultrasonic Attenuation of β-Ag_3SI
- ^B Nuclear Spin-Lattice Relaxation in Itinerant Weak Antiferromagnetic SmRh_3B_2
- Ultrasonic Measurements in the Ionic Conductor β-Ag_3SI
- Coherent-Anomaly Method in Critical Phenomena.III.Mean-Field Transfer-Matrix Method in the 2D Ising Model
- Coherent Anomaly Method in Critical Phenomena.I.
- Trimer V^ Spin Singlet State and Pseudo Gap in LiVS_2 Studied by ^V and ^7Li Nuclear Magnetic Resonance
- ROLE OF NEUTROPHIL ELASTASE IN ENDOTOXIN-INDUCED HEPATIC MICROCIRCULATORY DYSFUNCTION IN MICE
- ^B NMR Study of Magnetism in RRh_3B_2 (R = La, Ce, Nd, Sm, Eu and Gd)(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- ^Bi-NQR Investigation of the Non-magnetic Heavy-fermion Compound CeRhBi (Condensed Matter: Electronic Structure, Electrical, Magnetic and Optical Properties)
- Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis
- Nitric oxide generated by iNOS reduces deformability of Lewis lung carcinoma cells
- Prostanoid receptor in tumor-associated angiogenesis and tumor growth
- Adenylate Cyclase/Protein Kinase A Signaling Pathway Enhances Angiogenesis Through Induction of Vascular Endothelial Growth Factor In Vivo
- Structural Identification of Sulfated Tyrosine in Human Urine
- Asymmetry of the Quadrupole Satellite Lines of ^Na in NaNO_2
- Orientation Dependence of the Quadrupole Relaxation in NaNO_2
- Gradient-Elastic Tensor in Ferroelectric Sodium Nitrite, NaNO_2
- Nuclear Magnetic Resonance Acoustic Saturation of ^Na in Sodium Nitrite
- Laser Beam Diffraction Patterns by Standing Uitrasound in Crystals
- NMR Acoustic Saturation Study on the Strain Distribution in the Crystal Caused by Ultrasonics
- Double Nuclear Magnetic Resonance in NaClO_3 by Acoustic Excitation
- Roles of calcitonin gene-related peptide and prostaglandin I_2 in prevention of ethanol-induced gastric mucosal microcirculatory disturbances by mild irritant in rats
- Suppression of Dextran Sulfate Sodium-Induced Colitis in Kininogen-Deficient Rats and Non-peptide B_2 Receptor Antagonist-Treated Rats
- OE-301 Erythropoietin Promotes Angiogenesis by Prompting Platelets to be Adherent to Endothelial Cells in Hindlimb Ischemia in Mice(OE51,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) (H),Oral Presentation (English),The 73rd Annual Scien
- PJ-542 Role of VEGFR1 Tyrosine Kinase Signaling in Enhancement of Angionegesis in Acute Hind limb Ischemia(Molecular biology, vascular(02)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Cyclooxygenase-2 Inhibitors Attenuate Increased Blood Pressure in Renovascular Hypertensive Models, but Not in Deoxycorticosterone-Salt Hypertension
- Theoretical Study on Charge-Transfer Interaction between Acyl-CoA Dehydrogenase and 3-Thiaacyl-CoA Using Density Functional Method
- Involvement of the Renal Kallikrein-Kinin System in Furosemide-Induced Natriuresis in Rats
- Novel Screening Method for Potential Skin-Whitening Compounds by a Luciferase Reporter Assay
- Mustard Oil in "Shibori Daikon" a Variety of Japanese Radish, Selectively Inhibits the Proliferation of H-ras-Transformed 3Y1 Cells
- Failure of the Oxytocin-Induced Increase in Secretion of Urinary Kallikrein in Young Spontaneously Hypertensive Rats
- Increase in Vascular Sensitivity to Angiotensin II and Norepinephrine after Four - Day Infusion of 0.3M Sodium Chloride in Conscious Kininogen - Deficient Brown Norway Katholiek Rats
- Oxytocin-Induced Natriuresis Mediated by the Renal Kallikrein-Kinin System in Anesthetized Male Rats
- Induction Mechanism of Small Intestinal Lesions Caused by Intravenous Injection of Endotoxin in Rats
- A Novel Model of Pain Sensation Using Superfused Gastrosplenic Omentum Preparation of Anesthetized Rats
- Spin Dynamics Studied by ^Y NMR in High T_c Superconductor YBa_2Cu_3O_
- Genistein Induced Apoptotic Cell Death in Adult T-Cell Leukemia Cells through Estrogen Receptors
- A Potential Role of Bradykinin in Angiogenesis and Growth of S-180 Mouse Tumors
- Significant Roles of Inducible Cyclooxygenase (COX)-2 in Angiongenesis in Rat Sponge Implants
- Induction of Cyclooxygenase Type - 2(COX - 2) in Rat Endometrium at the Peak of Serum Estradiol during the Estrus Cycle
- Hyperglycemia-induced Alteration in Proteomes of the Rat Renal Cortex
- Study of Coherent Anomalies and Critical Exponents Based on High-Level Cluster-Variation Approximations
- RELIABLE EVIDENCE OF INVOLVEMENT OF THE KININ SYSTEM IN MOUSE MALARIA
- Characterization of Denitrifying Polyphosphate-Accumulating Organisms in Activated Sludge Based on Nitrite Reductase Gene(Environmental Biotechnology)
- Quinone Profiles Reflecting Population Dynamics of Denitrifying Phosphate-Accumulating Organisms
- Direct observation of microcirculation of the basal region of rat gastric mucosa
- Correlation Inequalities and Lower Bounds for the Critical Value λ_c of Contact Processes
- Applications of the CAM Based on a New Decoupling Procedure of Correlation Functions in the One-Dimensional Contact Process
- ACCELERATION OF ENDOGENOUS PGI2 GENERATION FROM ISOLATED RAT AORTAE BY MK-447
- DUAL EFFECTS OF A BASIC ANTI-INFLAMMATORY AGENT, 2-AMINOMETHYL-4-t-BUTYL-6-IODOPHENOL HYDROCHLORIDE (MK-447), ON BIOSYNTHESIS OF PROSTAGLANDIN ENDOPEROXIDES
- A Second-Order Phase Transition as a Limit of the First-Order Phase Transitions-Coherent Anomalies and Critical Phenomena in the Potts Models-
- Roles of Arachidonate Metabolites in Thrombus Formation and Leukocyte Migration : Analyses At Microcirculatory Level
- Upper Bounds for Order Parameters of a Class of Attractive Nearest-Particle Systems with Finite Ranges
- Applications of the Harris-FKG Inequality to Upper Bounds for Order Parameters in the Contact Processes
- Three-Point Markov Extension and an Improved Upper Bound for Survival Probability of the One-Dimensional Contact Process
- Extreme value distributions of noncolliding diffusion processes (Spectra of Random Operators and Related Topics)
- Coherent Anomaly Method in Critical Phenomena.II.Applications to the Two-and Three-Dimensional Ising Models
- Coherent-Anomaly Method in Critical Phenomena.V. Estimation of the Dynamical Critical Exponent Δ of the Two-Dimensional Kinetic Ising Model
- Statistical Properties of Trajectories of Friendly Walkers on Spatio-Temporal Plane : General Physics
- New Method to Study Critical Phenomena-Mean-Field Finite-Size Scaling Theory
- Scaling Laws of the Nonlinear Part of Magnetization in the SK Model of Spin Glasses : Condensed Matter and Statistical Physics
- Structural and Statistical Properties of Competing Directed Percolation
- On the CAM Canonicality of the Cluster-Variation Approximations
- The Number of Directed Compact Site Animals and Extrapolation Formula of Directed Percolation Probability
- Study of Coherent Anomalies and Critical Exponents Based on the Cluster-Variation Method
- n-State Exclusive diffusion Models for Avalanche Processes Showing Self-Organized Criticality
- Low-Density Series Expansion for the Domany-Kinzel Model : General Physics
- Analysis of Canopy-Gap Structures of Forests by Ising-Gibbs States-Equilibrium and Scaling Property of Real Forests-
- Exclusive Diffusion Model Showing Self-Organized Criticality
- Chiral Potts Models,Friendly Walkers and Directed Percoltion Problem
- Biphasic Accumulation of Leukocytes in Rat Cardiac Infarct Tissue Caused by Leukotriene B4 and Complement
- Pivotal Role of Renal Kallikrein-Kinin System in the Development of Hypertension and Approaches to New Drugs Based on This Relationship
- Characterization of the Triphenyltin-Induced Increase in Intracellular Ca2+ of Mouse Thymocytes: Comparison with the Action of A23187
- The Effects of Intracerebroventricular Administration of α1-Adrenoceptor Affecting Drugs on the Bloodpressure and Heart Rate in Conscious Rats
- A Stable Metabolite, Arg-Pro-Pro-Gly-Phe, of Bradykinin in the Degradation Pathway in Human Plasma.