Oxytocin-Induced Natriuresis Mediated by the Renal Kallikrein-Kinin System in Anesthetized Male Rats
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概要
- 論文の詳細を見る
Intravenous infusion of oxytocin (OT) (10- 100 nmol/kg/30 min) to 8-week-old anesthetized male rats resulted in a dose-dependent increase in urine volume, which showed a peak value 30-45 min after the start of OT-infusion. Urinary excretions of sodium, chloride and potassium were also increased by OT, showing peak values at 30 - 45 min, without any increase in the creatinine level. The natriuresis by OT was accompanied by increased excretion of urinary active kallikrein, which showed a peak value 15 min after the start of OT-infusion. The urinary kinin level was also increased. Intravenous infusion of a kallikrein inhibitor, aprotinin (15 mg/kg/90 min), when started 30 min before the OT-infusion, significantly inhibited the OT-induced increase in urine volume and urinary excretion of sodium, chloride and potassium. Intravenous infusion of a bradykinin B<SUB>2</SUB> antagonist, Hoe 140 (D-Arg[Hyp<SUP>3</SUP>, Thi<SUP>5</SUP>, D-Tic<SUP>7</SUP>, Oic<SUP>8</SUP>]BK, 4.5 mg/kg/90 min), when started 30 min before the OT-infusion, significantly inhibited the OT-induced increases in urine volume and urinary excretion of sodium and chloride, but not that of potassium. These results indicate that the OT-infusion induces natriuresis in male rats, and more than half of the natriuresis is mediated by a concomitant increase in excretion of urinary active kallikrein and the kinin generated.
- 社団法人 日本薬理学会の論文
- 1995-03-01
著者
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Majima Masataka
Department of Pharmacology, Kitasato University of Medicine
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NISHIJIMA Masahiro
Department of Biochemistry and Cell Biology, National Institute of Health
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KATORI Makoto
Department of Pharmacology, Kitasato University School of Medicine
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ADACHI Keiichi
Department of Chemistry, Shizuoka University
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Adachi Keiichi
Department Of Pharmacology Kitasato University School Of Medicine
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Adachi Keiichi
Department Of Chemistry Faculty Of Science Shizuoka University
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Katori M
Department Of Pharmacology Kitasato University School Of Medicine
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Katori Makoto
Dep. Of Pharmacology Kitasato Univ. School Of Medicine Jpn
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Katori Makoto
Department Of Pharmacology Kitasato University School Of Medicine
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Nishijima Masahiro
Department Of Biochemistry And Cell Biology National Institute Of Health
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Matsubara Madoka
Department Of Pharmacology Kitasato University School Of Medicine
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Majima Masataka
Department Of Orthopedic Surgery Yokkaichi Municipal Hospital
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Majima Masataka
Departmento Of Pharmacology Kitasato University School Of Medicine
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Nishijima M
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Majima M
Department Of Pharmacology Kitasato University School Of Medicine
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