DUAL EFFECTS OF A BASIC ANTI-INFLAMMATORY AGENT, 2-AMINOMETHYL-4-<I>t</I>-BUTYL-6-IODOPHENOL HYDROCHLORIDE (MK-447), ON BIOSYNTHESIS OF PROSTAGLANDIN ENDOPEROXIDES
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概要
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Effects of MK-447 on prostaglandin (PG) endoperoxide formation from arachidonic acid by bovine seminal vesicle microsomes in the presence of cofactors (hemoglobin and tryptophan) were studied by cascade superfusion on rabbit aorta and mesenteric artery and rat stomach and colon. In the presence of hemoglobin (0.2 μM), MK-447 (up to 30 μM) accelerated PG endoperoxide formation, as tryptophan did, whereas higher concentrations of MK-447 lost the acceleration effect and finally inhibited the PG endoperoxide formation. Increased concentration of hemoglobin (2 μM) shifted the dose of MK-447 for peak generation from 30 to 100 μM. Thus, MK-447 shows dual action, acceleration and inhibition, on the PG endoperoxide formation.
- 社団法人 日本薬理学会の論文
著者
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Tanaka Kunio
Department of Internal Medicine Tama-Nagayama Hospital, Nippon Medical School
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Katori Makoto
Department Of Pharmacology Kitasato University School Of Medicine
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Harada Yoshiteru
Department Of Pharmacology Kitasato University School Of Medicine
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Tanaka Kunio
Department Of Biology Nihon University School Of Medicine
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