A Stable Metabolite, Arg-Pro-Pro-Gly-Phe, of Bradykinin in the Degradation Pathway in Human Plasma.
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概要
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Degradation of bradykinin (BK) in human plasma was investigated by searching for a stable metabolite as a marker of kinin release in vivo. BK, incubated with diluted plasma, was degraded to des-Arg<SUP>9</SUP>-BK (des-9-BK), des-Phe<SUP>8</SUP>-Arg<SUP>9</SUP>-BK (des-8, 9-BK) and Arg-Pro-Pro-Gly-Phe ([1-5]BK). Des-9-13K was degraded to [1-5]BK without an increase in des-8, 9-BK, and des-8, 9-BK was also degraded to [1-5]BK. D, L-2-Mercaptomethyl-3-guanidinoethyl-thiopropanoic acid inhibited the formation of des-9-BK from BK, whereas captopril inhibited the formation of des-8, 9-BK from BK as well as that of [1-5]BK from des-9-BK or des-8, 9-BK. The half lives of BK, des-9-BK, des-8, 9-BK and [1-5]BK under the present experimental conditions were 60 min, 90 min, 14 min and 4.2 hr, respectively. Among the metabolites, [1-5]BK was the most stable one and may be used as a marker for BK production in vivo.
- 公益社団法人 日本薬理学会の論文
著者
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KATORI Makoto
Department of Pharmacology, Kitasato University School of Medicine
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Katori Makoto
Department Of Pharmacology Kitasato University School Of Medicine
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Majima Masataka
Department Of Orthopedic Surgery Yokkaichi Municipal Hospital
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Shima Chikako
Department Of Materials Science And Technology Faculty Of Science And Technology Hirosaki University
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Shima Chikako
Department of Pharmacology, Kitasato University School of Medicine
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