Prostanoid receptor in tumor-associated angiogenesis and tumor growth
スポンサーリンク
概要
- 論文の詳細を見る
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the cyclooxygenase (COX) enzyme and suppress PG synthesis which are used commonly as anti-inflammatory, anti-pyretic and analgestic agents. Though NSAIDs is known to suppress incidence and progression of cancer especially colorectal cancer, the precise mechanism of their protective effect remain unknown. A wide range of mechanism about anti-tumor effect of NSAIDs have been reported. Some of them are unrelated to the inhibition of COX activity and subsequent PG formation. However, recent result from by using knockout mice and selective antagonists indicated that prostanoid receptor, especially PGE2 enhances angiogenesis and tumor growth. Here, we summarize significant of PGE2 signaling via EP3 receptors which exists on the stroma but on tumor cells. An EP3 receptor antagonist may be a candidate of chemopreventive agents for malignant tumor.
- 日本炎症・再生医学会の論文
- 2005-01-25
著者
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Yoshimura Hirokuni
Department of Thoracic Surgery, Kitasato University School of Medicine
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Majima Masataka
Department of Pharmacology, Kitasato University of Medicine
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HAYASHI Izumi
Department of Electrical and Electronic Engineering, Tokyo Institute of Technology
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AMANO Hideki
Department of Thoracic Surgery, Kitasato University School of Medicine
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Yoshimura Hirokuni
Department Of Thoracic And Cardiovascular Surgery
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Amano Hideto
Department Of Thoracic And Cardiovascular Surgery
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Amano Hideki
Department Of Biology Faculty Of Science Kyushu University
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Hayashi Izumi
Department Of Pathophysiology Nippon Pharmaceutical University
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Hayashi Izumi
Department Of Pharmacology Kitasato University School Of Medicine
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Hayashi Izumi
Department Of Surgery Kitasato University
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Hayashi Izumi
Department Of Electrical And Electronic Engineering Faculty Of Engineering Tokyo Institute Of Techno
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Yoshimura Hiroyuki
Department Of Thoracic And Cardiovascular Surgery
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Matsubara Madoka
Department Of Pharmacology Kitasato University School Of Medicine
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Majima Masataka
Department Of Orthopedic Surgery Yokkaichi Municipal Hospital
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Majima Masataka
Departmento Of Pharmacology Kitasato University School Of Medicine
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Majima M
Department Of Pharmacology Kitasato University School Of Medicine
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