Differentiation of Kinin Fractions in Ureter Urine and Bladder Urine of Normal and Kininogen-deficient Rats
スポンサーリンク
概要
- 論文の詳細を見る
Like human kininogens-deficiency, the ureter urine of Brown Norway (B/N) Katholiek rat, a congenitally deficient strain in plasma high molecular weight (HMW)-and low molecular weight (LMW)-kininogen, showed no detectable kinin in the peptide fraction of gel chromatography, whereas normal ureter urine (B/N-Kitasato rat) expressed kinin in the peptide fraction, when assayed by bradykinin enzyme immunoassay (EIA). However there was immunoreactive substance in the higher molecular weight fraction in both strains of rat. The nature of this substance is not known, but it may give rise to a wrong estimate for kinin if rat urine is allowed to immunoassay directly, and peptide fraction of urine is not resolved into its components by gel chromatography. Kinin degrading activity in rat urine is so potent that kinin could be mostly degraded when stored in the bladder, since kinin was found in the peptide fraction of fresh ureter urine but not in that of bladder urine of the normal strain.
- 公益社団法人日本薬学会の論文
著者
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Nakano Takeshi
Department Of Cardiology Matsusaka Central General Hospital
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Hayashi Kyoko
Department Of Clinical Functional Physiology Toho University Medical Center Omori Hospital
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Nakano Takeshi
Riken Advanced Sci. Inst.
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Hayashi Masahiko
Department Of Earth System Science Faculty Of Science Fukuoka University
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Hayashi I
Department Of Pharmacology School Of Pharmaceutical Sciences:department Of Experimental Animal Scien
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Hayashi Izumi
Department Of Electrical And Electronic Engineering Faculty Of Engineering Tokyo Institute Of Techno
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Oh‐ishi S
Department Of Pharmacology School Of Pharmaceutical Sciences:department Of Experimental Animal Scien
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Ohishi Sachiko
Department Of Pharmacology Kitasato University School Of Pharmaceutical Sciences
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Yamaki Kohji
Department Of Pharmacology School Of Pharmaceutical Sciences Kitasato University
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Yamaki Kohji
Department Of Pharmacology School Of Pharmaceutical Sciences:department Of Experimental Animal Scien
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Nakano T
Riken Adavanced Science Institute
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YAMASU Akiko
Department of Pharmacology, School of Pharmaceutical Sciences
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SUNAHARA Noriyuki
Department of Pharmacology, School of Pharmaceutical Sciences
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Sunahara Noriyuki
Department Of Pharmacology School Of Pharmaceutical Sciences:department Of Experimental Animal Scien
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Hayashi Kyoko
Department Of Pharmacology School Of Pharmaceutical Sciences:department Of Experimental Animal Scien
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Hayashi Kyoko
Department Of Applied Chemistry Faculty Of Engineering Okayama University
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Nakano Takeshi
Department Of Biology Miyagi University Of Education
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Yamasu Akiko
Department Of Pharmacology School Of Pharmaceutical Sciences:department Of Experimental Animal Scien
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Hayashi Masahiko
Department Of Chemistry Graduate School Of Science Kobe University
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Hayashi Masahiko
Department Of Agricultural Biochemistry And Biotechnology Tottori University
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Hayashi Masahiko
Department Of Pharmacology School Of Pharmaceutical Sciences:department Of Experimental Animal Scien
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YAMAKI KOHJI
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University
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