Effects of Fucoidan from Mozuku on Human Stomach Cell Lines

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概要

• 論文の詳細を見る

• Cladosiphon okamuranus (Okinawamozuku) is a species of Mozuku known to contain the most fucoidan of any brown algae. Fucoidan is a sulfated hetero polysaccharide with various biological activities. We isolated and purified fucoidan from C. okamuranus. The yield of fucoidan was 1.0% (w/w) based on wet algae from C. okamuranus. The sulfate content and molecular weight of the fucoidan were 9.8% (w/w) and approximately 3,200,000, respectively. We examined the effects of fucoidan on human stomach cell lines. Fucoidan from C. okamuranus showed an inhibitory effect on anticancer agent 5-fluorouracil (5-FU) in Hs 677.st normal stomach cells with minimum inhibition of the original effect of 5-FU in cancer cells. Furthermore, fucoidan from C. okamuranus showed growth inhibition of stomach cancer cells but did not show any effects on normal cells. Thus, fucoidan from Mozuku, especially C. okamuranus, may be useful for cancer therapy.

• 社団法人　日本食品科学工学会の論文
• 2006-08-01

著者

• Takahashi N

  Plant Functions Laboratory Riken

• Tanaka K

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• KAWAMUKAI Makoto

  Department of Applied Bioscience and Biotechnology, Faculty of Life and Environmental Science

• MATSUDA Hideyuki

  Department of Applied Bioscience and Biotechnology, Faculty of Life and Environmental Science

• Tanaka Katsunori

  Department of Applied Bioscience and Biotechnology, Faculty of Life and Environmental Science, Shima

• Tanaka K

  Tottori Univ. Tottori

• NAKAGAWA Tsuyoshi

  Center for Integrated Research in Science, Shimane University

• Nakano Takeshi

  Riken Advanced Sci. Inst.

• Kimura Tetsuya

  Department Of Sustainable Resource Science Graduate School Of Of Bioresources Mie University

• Takahashi Nobutaka

  Frontier Research Program The Institute Of Physical And Chemical Research

• Takahashi Nobutaka

  Frontier Research Program The Institute Of Physical And Chemical Research (rlken)

• Nakagawa Tetsuto

  Department Of Bioscience And Biotechnology Division Of Bioresource And Bioenvironmental Sciences Gra

• Kawamoto Hitoshi

  Marine Products Kimuraya Co. Ltd.

• Nakagawa Tsuyoshi

  Dep. Of Molecular And Functional Genomics Center For Integrated Res. In Sci. Shimane Univ.

• Tanaka Kiyoshi

  Coll. Environ. Health Azabu Univ.

• NAKANO Takeshi

  The Institute of Physical and Chemical Research (RIKEN)

• MIKI Yasunari

  Marine Products Kimuraya Co., Ltd.

• KIMURA Takayuki

  Marine Products Kimuraya Co., Ltd.

• Yuasa Mihoko

  Marine Products Kimuraya Co. Ltd.

• Kawamukai Makoto

  Department Of Applied Bioscience And Biotechnology Faculty Of Life And Environmental Science Shimane

• Kimura Tetsuya

  Dep. Of Sustainable Resource Sci. Graduate School Of Bioresources Mie Univ.

• Nakagawa T

  Department Of Bioscience And Biotechnology Division Of Bioresource And Bioenvironmental Sciences Gra

• Morita K

  Department Of Applied Bioscience And Biotechnology Faculty Of Life And Environmental Science Shimane

• Kawamukai M

  Department Of Applied Bioscience And Biotechnology Faculty Of Life And Environmental Science Shimane

• Miki Yasunari

  Marine Products Kimuraya Co. Ltd.

• Takahashi Nobuyuki

  Hokkaido University Of Education

• Matsuda H

  Department Of Applied Bioscience And Biotechnology Faculty Of Life And Environmental Science Shimane

• Matsuda Hideyuki

  Department Of Applied Bioscience And Biotechnology Faculty Of Life And Environmental Science Shimane

• Nakagawa Tsuyoshi

  Center For Integrated Research In Science Shimane University

• Kawamukai Makoto

  Department Of Life Science And Biotechnology Faculty Of Life And Environmental Science Shimane Unive

• Nakano Takeshi

  Plant Functions Lab. The Inst. Of Physical And Chemical Res.

• Nakano Takeshi

  Plant Functions Lab.

• Kikuchi Takao

  Coll. Environ. Health Azabu Univ.

• Tanaka Keiko

  Department Of Food Science And Technology Faculty Of Agriculture Kyoto University

• Nakagawa Tsuyoshi

  Department Of Molecular And Functional Genomics Center For Integrated Research In Science Shimane Un

• Kawamukai Makoto

  Department Of Life Science And Biotechnology Faculty Of Life And Environmental Science Shimane Unive

• Takahashi Nobuyuki

  Laboratory For Molecular Function Of Food Division Of Food Science And Biotechnology Graduate School

• Koyanagi Takashi

  Research Institute For Bioresources And Biotechnology Ishikawa Prefectural University

• Takahashi Noriko

  Department of Molecular and Functional Genomics, Center for Integrated Research in Science, Shimane University

• Tanaka Kyoko

  Graduate School of Life and Environmental Sciences, Kyoto Prefectural University

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