Demonstration of kinin-release in the peritoneal exudate of kaolin-induced writhing in mice.
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概要
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Using a bradykinin enzyme immunoassay, we measured the amount of kinin in the peritoneal washings of mice with the kaolin-induced writhing reaction. Simultaneous treatment with captopril, a kininase II inhibitor, significantly increased the kinin level at 1 min after kaolin injection. Soybean trypsin inhibitor injected simultaneously with kaolin almost completely suppressed the kinin level at 1 min with or without treatment of captopril. These results suggest that kinin is released through activation of the plasma kallikrein-kinin system by kaolin, and that kinin could be a main mediator for the writhing reaction.
- 公益社団法人 日本薬理学会の論文
著者
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Hayashi Izumi
Department Of Electrical And Electronic Engineering Faculty Of Engineering Tokyo Institute Of Techno
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IIDA Hiroyuki
Pharmaceuticals Research Laboratories, Fujirebio Inc.
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IKEDA Kenro
Pharmaceuticals Research Laboratories, Fujirebio Inc.
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Fujiyoshi Toshio
Department Of Pharmacology Kitasato University School Of Pharmaceutical Sciences
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Dozen Masaharu
Pharmaceuticals Research Laboratories Fujirebio Inc.
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Oh-ishi Sachiko
Department Of Pharmacology School Of Pharmaceutical Sciences Kitasato University
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FUJIYOSHI Toshio
Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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DOZEN Masaharu
Pharmaceuticals Research Laboratories, Fujirebio, Inc.
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IIDA Hiroyuki
Pharmaceuticals Research Laboratories, Fujirebio, Inc.
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