Involvement of arachidonic acid metabolites in acute inflammation: Detection of 6-keto-PGF1.ALPHA., thromboxane B2 and PGD2 in rat pleurisy induced by phorbol myristate acetate.
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概要
- 論文の詳細を見る
Rat pleurisy was induced by intrapleural injection of phorbol myristate acetate (PMA), a known tumor promotor and a component of croton oil. Pleural fluids at 30 min and 1 hr after PMA-injection were collected and arachidonic acid metabolites in the fluids were measured by RIA or bioassay after fractionation through reversed phase HPLC using an ODS column. The major metabolites found in the pleural fluid were 6-keto-PGF<SUB>1α</SUB>, TXB<SUB>2</SUB> and PGD<SUB>2</SUB>, with a small amount of PGE<SUB>2</SUB>. Pretreatment with 10 mg/kg indomethacin suppressed the pleural fluid accumulation and also reduced the amount of the above metabolites to the basal levels. Treatment with OKY-046, a novel thromboxane synthetase inhibitor, reduced the level of TXB<SUB>2</SUB> completely, but had no effect on those of 6-keto-PGF<SUB>1α</SUB> and PGD<SUB>2</SUB>, and it had no effect on pleural fluid accumulation either. The results may indicate that PGI<SUB>2</SUB> plays a role for the vascular permeability increase in the early phase of pleurisy.
- 公益社団法人 日本薬理学会の論文
著者
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Oh-ishi Sachiko
Department Of Pharmacology School Of Pharmaceutical Sciences Kitasato University
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KIYOMIYA Ken-ichi
Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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