The Acyl-CoA Synthetase Inhibitor Triacsin C Enhanced Eicosanoid Release in Leukocytes.
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概要
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Triacsin C was previously reported to inhibit long-chain acyl-CoA synthetase and to reduce the production of acyl-CoA in rat neutrophils dose and time-dependently. We found that preincubation with triacsin C inhibited the incorporation of labeled arachidonic acid into rat neutrophils. Furthermore, when triacsin C-treated neutrophils were stimulated with the Ca-ionophore A23187, they released an increased amount of eicosanoids into the culture medium. These results indicate that triacsin C suppressed acylation of arachidonic acid, which resulted in an increase in its metabolites.
- 公益社団法人 日本薬理学会の論文
著者
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Yamaki Kohji
Department Of Pharmacology School Of Pharmaceutical Sciences Kitasato University
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Oh-ishi Sachiko
Department Of Pharmacology School Of Pharmaceutical Sciences Kitasato University
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Omura Satoshi
Kttasato Institute
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Abe Mitsuhiro
Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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Tomoda Hiroshi
Kttasato Institute
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