Mouse Paw Edema Induced by a Novel Bradykinin Agonist and Its Inhibition by B2-Antagonists
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概要
- 論文の詳細を見る
A novel non-peptide bradykinin B2-receptor agonist, FR190997 (8-[2, 6-dichloro-3-[N-[(E)4-(N-methylcarbamoyl)cinnamidoacetyl]-N-methylamino]benzyloxy]-2-methyl-4-(2-pyridylmethoxy) quinoline), induced dose-dependent and longer-lasting swelling than bradykinin in the mouse paw. The swelling, peaking around 30 min, was suppressed dose-dependently by intraperitoneal administration of FR173657, a novel non-peptide B2-receptor antagonist. A known B2-antagonist, Hoe 140, also significantly suppressed this edema. The result indicates that the novel B2-agonist FR190997, being more stable than bradykinin, could induce plasma exudation locally in mice via the B2-receptor as a substitute for bradykinin.
- 社団法人 日本薬理学会の論文
著者
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NARABA Hiroaki
Department of Epidemiology, Research Institute, National Cardiovascular Center
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Naraba Hiroaki
Department Of Pharmacology School Of Pharmaceutical Sciences Kitasato University
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Ohishi Sachiko
Department Of Pharmacology Kitasato University School Of Pharmaceutical Sciences
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Ueno Akinori
Department Of Pharmacology School Of Pharmaceutical Sciences Kitasato University
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OH-ISHI Sachiko
Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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Naraba Hiroaki
Department Of Cardiology National Cerebral And Cardiovascular Center
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Oh-ishi Sachiko
Department Of Pharmacology School Of Pharmaceutical Sciences Kitasato University
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