The Mediators Involved in Endotoxin-Induced Vascular Permeability Increase in the Rat Skin and Their Interactions
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概要
- 論文の詳細を見る
The injection of lipopolysaccharide (LPS) from <I>E. Coli</I> into the dorsal skin of rats caused a dose-dependent increase in vascular permeability as measured by the extravasation over a 40-min period of intravenously injected dye. This increase caused by LPS was attenuated by pretreatment with the bradykinin (BK) receptor antagonist HOE140, the selective platelet-activating factor (PAF) antagonist TCV309, and by combined treatment with mepyramine and methysergide. Combined treatment with HOE140 and TCV309 resulted in further suppression than that achieved with a single treatment alone. By the simultaneous pretreatment with all antagonists, the response was almost totally abolished. On the other hand, indomethacin also inhibited the response induced by LPS, but not those induced by BK and PAF itself. A small dose of BK or histamine synergistically potentiated the effect of PAF when simultaneously injected. These results suggest that BK, PAF, histamine/serotonin and prostaglandins are involved in the LPS-induced increase in vascular permeability, where PAF, in addition to its direct action, potentiates the response to BK and histamine, and prostaglandins potentiate the actions of other mediators without its direct action.
- 社団法人 日本薬理学会の論文
- 1996-04-01
著者
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NARABA Hiroaki
Department of Epidemiology, Research Institute, National Cardiovascular Center
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Naraba Hiroaki
Department Of Pharmacology School Of Pharmaceutical Sciences Kitasato University
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Ueno Akinori
Department Of Pharmacology School Of Pharmaceutical Sciences Kitasato University
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OH-ISHI Sachiko
Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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TOKUMASU Takaki
Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato Univesity
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Naraba Hiroaki
Department Of Cardiology National Cerebral And Cardiovascular Center
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Tokumasu Takaki
Department Of Pharmacology School Of Pharmaceutical Sciences Kitasato Univesity
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Oh-ishi Sachiko
Department Of Pharmacology School Of Pharmaceutical Sciences Kitasato University
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