Assessment of vascular permeability increase in the mouse by dye leakage during paw edema.
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概要
- 論文の詳細を見る
Vascular permeability increase induced by histamine, bradykinin, plateletactivating factor (PAF), or phorbol myristate acetate (PMA) in the mouse paw was assessed by the dye leakage method. The amount of dye extracted from the paw showed a clear dose-response relationship to the dose of each agonist injected into the paw. Among the autacoids used, PAF showed the most potent activity in the mouse paw. The results are consistent with those seen in the rat dorsal skin as previously reported. Involvement of histamine, 5-hydroxytryptamine and PAF is suggested in the vascular permeability increase induced by PMA in the mouse paw.
- 公益社団法人 日本薬理学会の論文
著者
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Oh-ishi Sachiko
Department Of Pharmacology School Of Pharmaceutical Sciences Kitasato University
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Hayashi Masahiko
Department Of Agricultural Biochemistry And Biotechnology Tottori University
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QU Xiao
Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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YAMAKI KOHJI
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University
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