Characterization of the activity of a platelet activating factor antagonist, CV-3988.
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概要
- 論文の詳細を見る
CV-3988 inhibited the vascular permeability increase induced by C<SUB>16</SUB>-PAF and C<SUB>18</SUB>-PAF in rat skin in a dose-dependent manner. The inhibition was shown to be specific and competitive with PAF on its receptor by the following observations: 1) Parallel shift of the dose-response curve; 2) Crossing of double reciprocal plots on the intersection of the ordinate; and 3) No inhibition on other autacoids such as bradykinin, histamine, 5-hydroxytryptamine and LTC<SUB>4</SUB>. PAF-induced blood pressure fall in rats was also suppressed by pretreatment with CV-3988 selectively.
- 公益社団法人 日本薬理学会の論文
著者
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Kimura Junko
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Toho University
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Oh-ishi Sachiko
Department Of Pharmacology School Of Pharmaceutical Sciences Kitasato University
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Hayashi Masahiko
Department Of Agricultural Biochemistry And Biotechnology Tottori University
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TSUSHIMA Susumu
Central Research Division, Takeda Chemical Industries, Ltd.
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NOMURA Hiroaki
Central Research Division, Takeda Chemical Industries, Ltd.
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Nomura Hiroaki
Central Research Division, Takeda Chemical Ind., Ltd.
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